Ding et al., Acta Pharmacol Sin 2012
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GLP-1R antagonist exendin ( 9-39 ) or DPP-4 inhibitor sitagliptin, which abolished GLP-1 ( 9-36 ) formation, at the concentration of 5000 pmol/L partially blocked the effects of GLP-1 on eNOS Chai et al., Diabetes 2012
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After confirming that GLP-1 potently stimulates nitric oxide ( NO ) synthase ( NOS ) phosphorylation in endothelial cells, overnight fasted adult male rats received continuous GLP-1 infusion ( 30 pmol/kg/min ) for 2 h plus or minus NOS inhibition
Ding et al., Zhonghua Yi Xue Za Zhi 2012
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GLP-1 ( 9-36 ) can increase NO release, eNOS activity and expression in HUVEC