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MYLIP — TXNIP

Text-mined interactions from Literome

Zhuo et al., J Biol Chem 2010 : Vitamin D3 up-regulated protein 1(VDUP1) is regulated by FOXO3A and miR-17-5p at the transcriptional and post-transcriptional levels, respectively, in senescent fibroblasts
Xu et al., Nat Med 2013 (Diabetes Mellitus, Experimental) : In particular, we first discovered the regulation of miR-204 by TXNIP by microarray analysis, followed by validation studies in INS-1 beta cells, islets of Txnip-deficient mice, diabetic mouse models and primary human islets ... We then further found that TXNIP induces miR-204 by inhibiting the activity of signal transducer and activator of transcription 3 ( STAT3 ), a transcription factor that is involved in miR-204 regulation ... Taken together, our results demonstrate that TXNIP controls microRNA expression and insulin production and that miR-204 is involved in beta-cell function