Shin et al., Mol Cells 1999
:
These results suggest that the overexpression of alpha3beta1 integrin and the constitutive activation of Erk1/2 play a key role in the alteration of the angiogenic properties of ECV304 cells
Seo et al., Microvasc Res 2008
(MAP Kinase Signaling System) :
Collectively, our results indicate that TIMP-2 inhibits FGF-2 signaling pathways through association with integrin alpha3beta1 and Shp-1 dependent inhibition of p42/44(MAPK) signaling, which in turn, results in suppression of FGF-2 stimulated endothelial cell mitogenesis