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IL8 — RBBP7
Text-mined interactions from Literome
Ashburner et al., Mol Cell Biol 2001
:
Finally, we show that inhibition of
HDAC activity with TSA
causes an increase in both basal and TNF induced expression of the NF-kappaB regulated
interleukin-8 (IL-8) gene
Rahman et al., Biochem Pharmacol 2002
(Pneumonia) :
Pharmacological inhibition of
HDAC leads to the increased HAT activity, AP-1 and NF-kappaB activation, and
IL-8 release by H2O2 or TNF-alpha treatments
Schmeck et al., J Immunol 2008
:
Legionella induced histone modification as well as
HAT-/HDAC dependent
IL-8 release could also be shown in primary lung epithelial cells
Chavey et al., Mol Pharmacol 2008
(Breast Neoplasms) :
Moreover, run-on and transfection experiments demonstrated that
IL-8 induction by
HDAC inhibitors was transcriptional and involved mainly the nuclear factor-kappaB (NF-kappaB) site of the IL-8 promoter ... In summary, our results demonstrate that NF-kappaB pathway repression by
HDAC is
responsible for the low expression of
IL-8 in ERalpha positive breast cancer cells