Gene interactions and pathways from curated databases and text-mining

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IL8 — MAP3K1

Text-mined interactions from Literome

Holtmann et al., Mol Cell Biol 1999 (MAP Kinase Signaling System) : Consistently, the MAP kinase kinase kinase MEKK1 , which can activate NF-kappaB, SAPK/JNK, and p38 MAP kinases, most potently induced IL-8 formation
O'Reilly et al., Biochem Biophys Res Commun 2003 : Furthermore full length and C-terminal A20 showed similar regulatory effects on MEKK-1 activation of NF-kappa B and AP-1 and induction of IL-8
Nemoto et al., Mol Cell Biol 1998 : MEKK1 is activated by tumor necrosis factor alpha (TNF-alpha) and interleukin-1 and can potentiate the stimulatory effect of TNF-alpha on IKK and NF-kappaB activation