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IL6 — XIAP

Text-mined interactions from Literome

Yamagiwa et al., Cancer Res 2004 (Cholangiocarcinoma) : Translational regulation of x-linked inhibitor of apoptosis protein by interleukin-6 : a novel mechanism of tumor cell survival ... Our findings that IL-6 translationally regulates X-linked inhibitor of apoptosis protein expression reveal a novel mechanism by which IL-6 mediates tumor cell survival that may be targeted therapeutically to decrease tumor progression and chemoresistance
Resch et al., Pharmacol Rep 2006 (MAP Kinase Signaling System) : X-linked inhibitor of apoptosis protein regulates human interleukin-6 in umbilical vein endothelial cells via stimulation of the nuclear factor-kappaB and MAP kinase signaling pathways ... Pharmacologic inhibition of extracellular signal regulated kinase ( ERK ) kinases ( MEK1/2 ) as well as inhibition of the p38 signaling pathway both reduced XIAP induced IL-6 promoter activity ... In conclusion, these results suggest that XIAP regulates IL-6 transcription via NF-kappaB in cooperation with AP1 and C/EBP-beta