Gene interactions and pathways from curated databases and text-mining

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IL6 — SOD2

Text-mined interactions from Literome

Ono et al., Biochem Biophys Res Commun 1992 (Carcinoma, Hepatocellular...) : Induction of Mn-superoxide dismutase by tumor necrosis factor, interleukin-1 and interleukin-6 in human hepatoma cells ... Effects of Tumor Necrosis Factor (TNF), Interleukin-1 (IL-1), Interleukin-6 (IL-6) and Interferon-gamma (IFN-gamma) on the expression of Mn-superoxide dismutase ( Mn-SOD ) protein were investigated in human hepatoma cells, Hu-H1, which revealed resistance to the cytotoxicity of TNF and IL-1
El-Assal et al., Cell Mol Immunol 2004 (Hepatitis, Alcoholic...) : Finally, IL-6 treatment induces metallothionein protein expression, but not superoxide dismutase and glutathione peroxidase in cultured hepatocytes
Tsan et al., Am J Physiol 1992 (Anoxia) : However, IL-6 markedly enhances TNF-alpha- and IL-1 induced increases in Mn SOD mRNA levels and O2 tolerance
Zi et al., Zhonghua Nan Ke Xue 2006 : IL-6 could induce the activity of acrosin and superoxide dismutase ( SOD ) and enhance AR in human sperm
Nandi et al., Immunobiology 2010 (Endotoxemia) : Current data also demonstrate the critical role of IL-6 in inducing SOD in liver, whereas IL-6 prior and after LPS challenge group showed reduced PMN infiltration in the liver as evident by decreased hepatic MPO content in those mice
Jung et al., Stroke 2011 (Brain Ischemia...) : This study demonstrates that IL-6 has a neuroprotective effect against cerebral ischemic injury through IL-6R mediated STAT3 activation and manganese-superoxide dismutase expression
Zhu et al., Nan Fang Yi Ke Da Xue Xue Bao 2012 (Acute Lung Injury) : Compared with those in LPS group, IL-1ß, IL-6 , TNF-a and MDA in BALF, W/D, lung injury scores and iNOS mRNA and protein expression were significantly reduced and SOD in the BALF significantly increased in LPS+DAS group
Masuda et al., FASEB J 1988 : Induction of mitochondrial manganese superoxide dismutase by interleukin 1
Giełdanowski et al., Arch Immunol Ther Exp (Warsz) 1988 : Studies on the effect of superoxide dismutase ( peroxinorm ) on interleukin-1 activity
Kayanoki et al., J Biol Chem 1994 : While interleukin-1 beta and interleukin-6 induced manganese-superoxide dismutase gene expression, they slightly suppressed catalase gene expression in rat hepatocytes
Niwa et al., Am J Pathol 1993 : Both manganese SOD and copper, zinc SOD activities were significantly induced by paraquat, interleukin-1 , tumor necrosis factor, adriamycin, and bleomycin in lymphocytes and neutrophils from asymptomatic non aged adults, whereas neither activity was induced in aged individuals