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IL6 — NOS2

Text-mined interactions from Literome

Galley et al., Crit Care Med 1999 (Shock, Septic) : To determine the effect of the nitric oxide synthase inhibitor, L-N ( G ) -monomethylarginine, on interleukin-6 and interleukin-8 accumulation, and nuclear factor-kappaB expression in an endothelial cell model of sepsis
Heitmeier et al., J Biol Chem 1999 (Insulinoma) : Prolonged STAT1 activation is associated with interferon-gamma priming for interleukin-1 induced inducible nitric-oxide synthase expression by islets of Langerhans
Nédélec et al., Biochem Pharmacol 2001 : In monolayers, interleukin-1beta (IL-1beta) induced COX-2 and NOS II expression in a dose- and time dependent manner, to produce high prostaglandin E ( 2 ) ( PGE ( 2 ) ) and nitrite ( NO ( 2 ) ( - ) ) levels in an apparently coordinated fashion
Hirose et al., J Periodontol 2001 (Actinobacillus Infections...) : The expression of IL-6 may reflect inflammation in gingival tissue, and iNOS may be involved in the inflammatory process in periodontitis
Svensson et al., Microb Pathog 2001 : Furthermore, co-incubating S. typhimurium with Mphi resulted in interleukin (IL)-12p40, IL-6 and tumor necrosis factor-alpha production as well as iNOS induction while IL-12p70 was not detectable
Knuefermann et al., Circulation 2002 (Inflammation...) : Myocardial tumor necrosis factor, interleukin-1beta (IL-1beta), and NOS2 induction was measured before and 6 hours after LPS challenge
Xiong et al., J Biol Chem 2003 : In addition, interleukin-4 inhibits IFN-gamma induced iNOS gene expression by attenuating the physical interaction of ICSBP with IRF-1
Yu et al., J Biol Chem 2003 : JAK2/STAT3, not ERK1/2, mediates interleukin-6 induced activation of inducible nitric-oxide synthase and decrease in contractility of adult ventricular myocytes
Kankuri et al., Scand J Gastroenterol 2003 (Colitis, Ulcerative) : Selective inhibition of iNOS suppressed the release of tumour necrosis factor alpha ( TNF-alpha, by 66 % ) and interleukin-6 ( IL-6, by 27 % )
Miljkovic et al., Cell Mol Life Sci 2003 : The role of interleukin-17 in inducible nitric oxide synthase mediated nitric oxide production in endothelial cells
Hida et al., Free Radic Biol Med 2003 : We conclude that colloidal-iron phagocytosed by liver Kupffer cells enhanced LPS induced NO production in vivo, iNOS induction in the liver, and release of IL-6 , IL-1beta, and TNF-alpha
Cattaruzza et al., J Biol Chem 2003 : Interleukin-10 induction of nitric-oxide synthase expression attenuates CD40 mediated interleukin-12 synthesis in human endothelial cells
Okada et al., Int Immunol 2003 : Overexpression of NF-IL6 in activated RAW264 cells augmented iNOS promoter activity and reduced the regulatory effect of c-fos overexpression
Hierholzer et al., Am J Physiol Gastrointest Liver Physiol 2004 (Enteritis...) : Selective iNOS inhibition in shocked animals reduced the binding activity of NF-kappaB and Stat3 and reduced mRNA levels of ICAM-1, IL-6 , and G-CSF
Miljkovic et al., Cytokine Growth Factor Rev 2004 (Inflammation...) : Inducible nitric oxide synthase activation by interleukin-17
Leindler et al., Pancreas 2004 (Ischemia...) : The aim of our study was to determine the production of cytokines, tumor necrosis factor (TNF) and interleukin-6 (IL-6) , the activation of the inducible nitric oxide synthase (iNOS) , and the development of apoptosis during this pathologic process
Lee et al., Exp Cell Res 2004 (Bone Resorption) : In this study, we found that TNF-alpha, but not receptor activator of nuclear factor kappa B ligand and interleukin 1, increased the expression of iNOS both at the mRNA and protein levels
Davis et al., Alcohol 2004 : Results from a previous study in our laboratory, in the human A172 astroglial cell line, revealed that induction of iNOS activity by tumor necrosis factor-alpha + interferon-gamma + interleukin-1 beta was inhibited by 24-h exposure to a high ethanol concentration ( 200 mM ), but enhanced by 50 mM ethanol
Dawn et al., Cardiovasc Res 2004 (Myocardial Infarction...) : However, following a PC stimulus, IL-6 is obligatorily required for the activation of the JAK-STAT pathway, the ensuing upregulation of iNOS and COX-2 ( co-mediators of late PC ), and the development of a cardioprotective phenotype
Ortega-Gutiérrez et al., FASEB J 2005 (Multiple Sclerosis) : Additionally, in microglial cells, UCM707 decreases the production of the proinflammatory cytokines tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, and IL-6 ; reduces nitric oxide levels and inducible nitric oxide synthase expression ; and is able to potentiate the action of a subeffective dose of the endocannabinoid anandamide
Kaplin et al., J Clin Invest 2005 (Inflammation...) : IL-6 was necessary and sufficient to mediate cellular injury in spinal cord organotypic tissue culture sections through activation of the JAK/STAT pathway, resulting in increased activity of iNOS and poly ( ADP-ribose ) polymerase ( PARP )
Zheng et al., J Biol Chem 2006 (Bone Resorption) : Using murine RAW 264.7 and primary bone marrow cells or osteoclasts formed from them by receptor activator of NF-kappaB ligand ( RANKL ) differentiation, we found that inducible nitric-oxide synthase (iNOS) expression and NO generation were stimulated by interferon (IFN)-gamma or lipopolysaccharide, but not by interleukin-1 or tumor necrosis factor-alpha
Saura et al., J Biol Chem 2006 : Stat3 mediates interleukin-6 [ correction of interelukin-6 ] inhibition of human endothelial nitric-oxide synthase expression
Ma et al., Int J Cancer 2008 (Carcinoma...) : In vitro cell system, nuclear accumulation of EGFR was observed in LMP1 expressing cells, and IL-6 induced phosphorylated STAT3 and iNOS
Sun et al., Nan Fang Yi Ke Da Xue Xue Bao 2008 : The expression of inducible nitric oxide synthase (iNOS) was induced in cultured neonatal rat CMs by stimulation with lipopolysaccharide (LPS) and interleukin-6 (IL-6) for 24 h, and quantitatively measured using Western blotting
Hung et al., J Hypertens 2010 (Atherosclerosis) : Interleukin-6 inhibits endothelial nitric oxide synthase activation and increases endothelial nitric oxide synthase binding to stabilized caveolin-1 in human vascular endothelial cells
Fenton et al., Mol Carcinog 2010 (Carcinoma...) : Nitric oxide ( NO ) production was increased in MC-38 cells treated with IL-6 ; co-treatment with adiponectin blocked IL-6 induced iNOS and subsequent NO production
Fu et al., Journal of neuroinflammation 2010 : This activation of IDO by direct application of LPS was preceded by synthesis and secretion of TNFalpha and IL-6 protein and activation of iNOS while IFN gamma expression was undetectable
Xu et al., Biochem Biophys Res Commun 2011 (Cardiovascular Diseases...) : Knock-down of RSK1 selectively down regulated interleukin-1ß induced iNOS expression without influencing VCAM-1 expression
Cho et al., J Nutr Biochem 2012 : Effects of physiological quercetin metabolites on interleukin-1ß induced inducible NOS expression
Seo et al., Immunopharmacol Immunotoxicol 2012 (Inflammation) : SPEE treatment significantly inhibited the LPS induced production of NO, prostaglandin E ( 2 ), interleukin-6 , and tumor necrosis factor-a and inhibited the expression of iNOS and COX-2 via attenuation of NF-?B p65 expression
da Silva Krause et al., J Endocrinol 2012 : IL6 dramatically increased iNOS expression ( by ca. 100-fold ) with an accompanying tenfold rise in nitrite release in clonal ß-cells
Wang et al., Toxicological sciences : an official journal of the Society of Toxicology 2013 (Cystitis...) : Involvement of interleukin-6 regulated nitric oxide synthase in hemorrhagic cystitis and impaired bladder contractions in young rats induced by acrolein, a urinary metabolite of cyclophosphamide ... The iNOS inhibitors significantly inhibited the acrolein increased nitrite/nitrate levels, but not IL-6 levels
Qu et al., Evidence-based complementary and alternative medicine : eCAM 2012 : In addition, TSAV attenuated the serum TNF-a and IL-6 levels and inhibited the serum iNOS and NO levels
Fahmi et al., Cell Signal 2013 (Hypertrophy...) : IL-6 and pheneylephrine ( PE ), but not LIF, induced cardiomyocyte iNOS expression and nitric oxide ( NO ) production
Chung et al., Anesth Analg 2013 (Acute Lung Injury...) : ROS scavenger administration before isoflurane abolished the isoflurane preconditioning effect as well as isoflurane induced inhibition of phosphorylation of inhibitory ?Ba, NF?B p65, iNOS activation , and mRNA expression of TNF-a and IL-6 in acute LPS challenged lungs
Ning et al., PloS one 2013 (Inflammation...) : In addition, NaHS treatment prevented the increase of nitric oxide, Intercellular Adhesion Molecule 1 ( ICAM-1 ) and interleukin (IL)-6 production and inducible nitric oxide synthase activation induced by TNF-a
Ryu et al., Planta Med 2013 : Consistent with these observations, echinocystic acid concentration-dependently inhibited lipopolysaccharide induced inducible nitric oxide synthase expression at the protein level and inducible nitric oxide synthase, tumor necrosis factor-a, and interleukin-6 expression at the mRNA level, and inhibited lipopolysaccharide induced iNOS promoter binding activity
Singh et al., J Biol Chem 1995 : In vitro, interleukin-1 beta and interferon-gamma increased osteopontin mRNA levels in CMEC as well as NOS2 expression in both CMEC and cardiac myocytes
Szabó et al., Eur J Pharmacol 1993 : We investigated the role of interleukin-1 in the induction of a Ca ( 2+ ) -independent nitric oxide ( NO ) synthase by bacterial endotoxin in vivo
Tetsuka et al., Proc Natl Acad Sci U S A 1994 : Cross-talk between cyclooxygenase and nitric oxide pathways : prostaglandin E2 negatively modulates induction of nitric oxide synthase by interleukin 1
Kanno et al., Hypertension 1993 : Induction of nitric oxide synthase gene by interleukin in vascular smooth muscle cells
Duval et al., Mol Pharmacol 1996 : NOS2 activity was induced by lipopolysaccharide, IL-1 beta, TNF alpha, and IFN gamma but not by IL-6
Flak et al., Am J Respir Crit Care Med 1996 (Asthma...) : The induction of iNOS is most likely due to the cytokine interleukin-1 , which is generated intracellularly in response to TCT ; this cytokine, like TCT, can reproduce the pathology caused by B. pertussis infection
Heitmeier et al., J Biol Chem 1997 : Interferon-gamma increases the sensitivity of islets of Langerhans for inducible nitric-oxide synthase expression induced by interleukin 1
Sawada et al., J Immunol 1997 : Because region I possesses basal promoter activity and directly mediates iNOS gene activation, we attempted to identify the trans acting factors involved in IL-6 stimulated induction of the murine iNOS gene through this region ... Mutation of the octamer motif disrupted both binding of the IL-6 induced protein-DNA interactions and transcriptional activation through region I, revealing that this motif is absolutely essential for IL-6 induction of iNOS ... Thus, differential activation of octamer binding transcriptional modulators from the POU family may be a novel mechanism of IL-6 mediated iNOS gene regulation
Hauber et al., Cell Immunol 1997 : We show that gene expression of IL-1 alpha, IL-1 beta, IL-6 , granulocyte-colony stimulating factor, and IL-10 was induced in both cell fractions, whereas increased mRNA levels of interferon-gamma and the inducible nitric oxide synthase were exclusively detected in the patients ' nonadherent MNCs
Birks et al., Coron Artery Dis 1997 (Heart Failure) : TNF-alpha and IL-6 may be produced in heart failure and may induce inducible NO synthase , resulting in NO production, which acts as a negative inotrope
Kinugawa et al., Circ Res 1997 : Forskolin, interleukin (IL)-6 , tumor necrosis factor (TNF)-alpha, or interferon (IFN)-gamma enhanced the LPS induced iNOS expression ... Combined stimulation of IL-6 and TNF-alpha also induced iNOS
Hierholzer et al., J Exp Med 1998 (Inflammation...) : Using the iNOS inhibitor N6- ( iminoethyl ) -L-lysine or iNOS knockout mice we found that the activation of the transcriptional factors nuclear factor kappaB and signal transducer and activator of transcription 3 and increases in IL-6 and G-CSF messenger RNA levels in the lungs and livers measured 4 h after resuscitation from hemorrhagic shock were iNOS dependent