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IL1R1 — IL6
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
IL6
→
IL1R1
(increases, IL6 Activity)
Evidence: Ligation of alpha 5 beta 1 using activating mAb JBS5 (which acts as agonist similar to FN N-terminal fragment) up-regulates the inflammatory mediators such as NO and PGE2 as well as the cytokines, IL-6 and IL-8. Furthermore, up-regulation of these proinflammatory mediators by alpha 5 beta1 integrin ligation is mediated via induction and autocrine production of IL-1 beta, because type II soluble IL-1 decoy receptor inhibits their production.
Text-mined interactions from Literome
Yuan et al., Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2002
(Disease Models, Animal) :
[
Effect of
interleukin-1 on expression of
interleukin-1 receptor in KM mice sciatic nerves before and after injuries ]
Bozza et al., J Immunol 2008
(Aspergillosis...) :
IL-1R signaling was
involved in Th17 cell activation by
IL-6 and TGF-beta in that limited inflammatory pathology and relative absence of Th17 cell activation were observed in IL-1RI ( -/- ) mice
Dahlén et al., J Immunotoxicol 2008
(Arthritis, Experimental) :
Interleukin-1 receptor antagonist ( IL-1Ra ) is a naturally occurring inhibitor of the pro-inflammatory
interleukin-1 mediated activation of the
interleukin-1 receptor (IL-1R)
Hunter et al., TheScientificWorldJournal 2010
(Peritonitis) :
Selective inhibitors of Kv11.1 regulate
IL-6 expression by macrophages in
response to
TLR/IL-1R ligands
Shemesh et al., Atherosclerosis 2012
(Aortic Diseases...) :
Interleukin-1 receptor type-1 in non-hematopoietic cells is the
target for the pro-atherogenic effects of
interleukin-1 in apoE-deficient mice
Bonin et al., J Biol Chem 1988
:
Modulation of
interleukin-1 receptor expression and
interleukin-1 response in fibroblasts by platelet derived growth factor
Heguy et al., J Biol Chem 1993
:
A chimeric type II/type I
interleukin-1 receptor can
mediate interleukin-1 induction of gene expression in T cells
Lacey et al., J Clin Invest 1993
:
IL-1
induces ( IL-1 ED50, 0.1 pM ) IL-6 production through the type 1
IL-1R as 35F5 antibodies block IL-1 stimulated
IL-6 production