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CSRP1 — IL6

Text-mined interactions from Literome

Margaglione et al., Haematologica 2001 : Interleukin-6 (IL-6) strongly regulates the production of C-RP
Vickers et al., Cardiovasc Res 2002 (Cardiovascular Diseases...) : Interleukin-6 (IL-6) regulates CRP gene expression ; a promoter polymorphism ( -174G/C ) of the IL-6 gene has been shown to influence IL-6 transcription but the relationship between genotype at this polymorphism and circulating levels of inflammatory markers remains unclear
Agrawal et al., Immunology 2003 : They raise the possibility, not as yet established, that NF-kappaB activation may be responsible for the synergistic effect of IL-1beta on IL-6 induced CRP expression
Hu et al., Diabetes 2004 (Diabetes Mellitus, Type 2...) : Elevated CRP levels are a strong independent predictor of type 2 diabetes and may mediate associations of TNF-alphaR2 and IL-6 with type 2 diabetes
Ilhan et al., World J Gastroenterol 2004 (Abdominal Pain...) : The levels of VEGF, CRP, PCT, IL-6 , MDA and NO in cancer patients were significantly higher than those in healthy controls and the levels of CRP , PCT, IL-6, MDA and NO were statistically increased in infection group when compared with non-infection group ( P < 0.001 )
Latkovskis et al., Eur J Immunogenet 2004 (Coronary Disease...) : Production of CRP is regulated by interleukin (IL)-1beta, IL-1 receptor antagonist and IL-6
Vitale et al., Maturitas 2005 (Cardiovascular Diseases) : Elevated C-reactive protein (CRP) levels due to of heightened vascular inflammatory state in vascular conditions are often associated with elevated interleukin-6 (IL-6) levels since during inflammation CRP production in the liver is induced by IL-6
Voleti et al., J Immunol 2005 : Mutation of the kappaB site decreased the synergistic effect of IL-1beta on IL-6 induced CRP expression
Singh et al., Arterioscler Thromb Vasc Biol 2006 : Also, CRP alone increased secretion of IL-8, IL-6 , and tumor necrosis factor from HMDMs and did not inhibit LPS induced secretion of these cytokines
Mantovani et al., Vascul Pharmacol 2006 (Cardiovascular Diseases...) : CRP and SAP are produced primarily in the liver in response to IL-6 , while PTX3 is produced by a variety of tissues and cells and in particular by innate immunity cells in response to proinflammatory signals and Toll-like receptor ( TLR ) engagement
Taylor et al., Inflammation 1991 (Carcinoma, Hepatocellular...) : Although alpha 2-M also binds IL-6, it did not alter IL-6 induced CRP production by the hepatoma cells
Lee et al., Am J Cardiol 2007 (Atherosclerosis) : The association of IL-6 was independent of CRP , but not vice versa, suggesting an effect of IL-6 on an earlier state of atherosclerosis
Chang et al., J Cardiovasc Pharmacol 2007 : Moreover, losartan did not suppress CRP 's effect on MCP-1 and IL-6 secretion unless a high dose ( > or =500 micromol/L ) of losartan was used
Paik et al., Clin Chim Acta 2007 (Body Weight...) : The present data showed that serum CRP levels and other CVD risk factors appeared more influenced by IL-6-572C > G rather than CRP SNPs ( -717G > A, 1444C > T, and 2147A > G ), however CRP levels and insulin resistance may be additively affected by IL-6-572 and CRP SNP, particularly when subjects with G/G genotype at IL-6-572 have allele variant at CRP SNPs
Castoldi et al., Clin Sci (Lond) 2007 (Diabetes Mellitus, Type 2) : A univariate analysis showed that the level of IL-1beta and IL-6 , obtained after 24 h of incubation of whole blood with LPS, increased significantly with increasing levels of hs-CRP and, after adjusting for potential confounders, IL-1beta still remained statistically significant
Dowton et al., Pediatr Res 1991 (Acute-Phase Reaction) : Studies of immature hamsters after birth show that the responses of CRP and SAA genes to lipopolysaccharide, tumor necrosis factor, IL-1, and IL-6 are reduced when compared with induction of mRNA accumulation for these acute phase reactants in adult animals
Nishikawa et al., J Immunol 2008 : Because human fetus liver cells failed to express c-Fos/STAT3/HNF-1alpha showed no CRP production, transcriptional complex formation of c-Fos/STAT3/HNF-1alpha is essential for the synergistic induction of CRP gene expression by IL-1 plus IL-6
Qi et al., Diabetes 2009 (Diabetes Mellitus...) : Because IL6R variants were previously associated with IL-6 levels, we tested whether the associations with CRP were independent of IL-6 and the interactions between IL6R variants and CRP in relation to diabetes risk
Enocsson et al., Arthritis Rheum 2009 (Bacterial Infections...) : The interference of all 12 IFNalpha subtypes with CRP promoter activity induced by IL-6 and IL-1beta was studied in a CRP promoter- and luciferase reporter transfected human hepatoma cell line, Hep-G2
Yap et al., Biochim Biophys Acta 1991 : It inhibits also the stimulatory effect of IL-1 and IL-6 on the synthesis of CRP and SAA
Pavcnik-Arnol et al., Eur J Pediatr Surg 2010 (Congenital Abnormalities...) : Median preoperative serum concentrations were : PCT 1.3 microg/l, IL-6 985 fmol/l, IL-8 51 pg/ml, CRP 6 mg/l. PCT increased insignificantly after surgery with a peak median concentration on POD 1 ( 2.0 microg/l ), but concentrations varied considerably between patients in the same category of surgery
Sun et al., Mol Cell Biochem 2011 : Adiponectin reduced IL-6 induced CRP mRNA levels in HepG ( 2 ) cells and CRP protein secretion
Garlanda et al., Curr Pharm Des 2011 (Atherosclerosis...) : CRP and SAP are produced primarily in the liver in response to IL-6 , while PTX3 is produced by a variety of tissues and cells and in particular by innate immunity cells in response to proinflammatory signals and Toll-like receptor ( TLR ) engagement
Ganapathi et al., Biochem J 1990 (Carcinoma, Hepatocellular...) : 157, 271-277 ], employing defined cytokines, had shown that induction of CRP in Hep 3B cells requires IL ( interleukin ) -6 plus IL-1, whereas, in the NPLC/PRF/5 cell line, IL-6 alone is effective
Lee et al., PloS one 2012 (Cardiovascular Diseases...) : CRP adjustment attenuated the effects but the association between IL-6 and all-cause and CVD mortality remained statistically significant, independent of CRP levels
Gouin et al., Ann Behav Med 2012 : Childhood abuse history moderated IL-6 levels but not TNF-a and CRP responses to daily stressors
Li et al., Pharmacol Rep 2012 (Cardiovascular Diseases...) : EGCG is able to inhibit Ang II- and IL-6 stimulated CRP expression in macrophages to produce an anti-inflammation by interfering with ROS generation
Zhou et al., Heart 2013 (Ion Channel Gating...) : In contrast, IL-6 augmented CRP expression in vessel rings stretched with mechanical strains of 3 and 5 g ( CRP mRNA, IL-6 : 11.367±1.68 and 12.78±0.76 vs vehicle : 7.27±0.88 and 8.3±0.91 folds, respectively ; CRP, IL-6 : 12.79±1.62 and 14.05±2.1 vs vehicle : 7.72±1.04 and 8.16±1.52 folds, respectively ; p < 0.05 vs 0 g group and vehicle control group ; n=5 ), and this effect was completely blocked by treatment with gadolinium III chloride hexahydrate ( GdCl3 )
Wang et al., Mol Cell Biochem 2013 : We demonstrated that DHA and EPA inhibited IL-6 induced CRP protein and mRNA expression, as well as reduced CRP promoter activity in HepG2 cells
Androsova et al., Zh Nevrol Psikhiatr Im S S Korsakova 2013 (Alzheimer Disease...) : Positive correlations between CRP and IL-6 may plausibly reflect an ability of IL-6 to induce the synthesis of CRP
Sakai et al., Rinsho Byori 1994 (Acute Disease...) : IL-6 increased rather rapidly than other acute phase proteins, and increases of CRP , TRF, AAT, AAG, CER, HAP and AMG followed
Zhang et al., Biochem J 1995 : While previous studies have indicated that IL-6 induces transcription of CRP , the mode of action of IL-1 has not been clearly defined
Shimetani et al., Nihon Rinsho Meneki Gakkai Kaishi 1997 (Liver Neoplasms, Experimental) : A cytokine IL-6 induced the CRP production in the presence of IL-1 beta, but did not affect the constitutive production of SAA
Lozanski et al., Biochem J 1997 (Carcinoma, Hepatocellular) : The ability of C2 and C6 to potentiate the effects of cytokines suggests that the sphingomyelin-ceramide pathway participates in induction of CRP and SAA by IL-6+IL-1beta under these experimental conditions, most likely by transducing the effects of IL-1beta ... C2 and C6 were unable to substitute for IL-1beta in enhancing IL-6 effects on CRP and SAA, consistent with other reports indicating that the sphingomyelin-ceramide pathway is only a single component of multiple necessary converging pathways for induction of many genes
Roubenoff et al., J Gerontol A Biol Sci Med Sci 1998 (Inflammation) : IL-6 production increased with increasing CRP , whereas IL-1RA was uniformly elevated in elderly subjects regardless of CRP