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EDN1 — HRAS

Pathways - manually collected, often from reviews:

• BioCarta roles of ß arrestin dependent recruitment of src kinases in gpcr signaling: Ligand/GPCR(+)/Arrestin/(SRC/Hck/c-Fgr) complex (CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-ARRB1-FGR_HCK_SRC) → RAS (HRAS) (modification, activates)

Text-mined interactions from Literome

Emala et al., Am J Physiol 1999 : Carbachol and endothelin-1 increased GTP bound p21(ras) in a pertussis toxin-sensitive manner [ ratio of [ 32P ] GTP to ( [ 32P ] GTP + [ 32P ] GDP ) : control, 30 +/- 1.7 ; 3 min of 1 microM carbachol, 39 +/- 1.1 ; 3 min of 1 microM endothelin-1, 40 +/- 1.2 ], whereas histamine, bradykinin, and KCl were without effect
Foschi et al., EMBO J 1997 : Biphasic activation of p21ras by endothelin-1 sequentially activates the ERK cascade and phosphatidylinositol 3-kinase