◀ Back to HRAS

BHLHE40 — HRAS

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: BHLHE40 → HRAS (increases, BHLHE40 Activity)
  Evidence: Oncogene-induced senescence is a cellular response that may be crucial for protection against cancer development1, 2, but its investigation has so far been restricted to cultured cells that have been manipulated to overexpress an oncogene. Here we analyse tumours initiated by an endogenous oncogene, ras, and show that senescent cells exist in premalignant tumours but not in malignant ones. Senescence is therefore a defining feature of premalignant tumours that could prove valuable in the diagnos...