El Mezayen et al., Immunol Lett 2007
(Inflammation...) :
Although the interaction of HMGB1 and HSP70 with TREM-1 induced I kappa B alpha and p38 expression, both of which are required for the inflammatory cytokine expression, blockade of TREM-1 did not affect I kappa B alpha expression but markedly reduced p38 activation, as revealed by Western blot analysis
Kawahara et al., Int J Mol Med 2008
(Atherosclerosis...) :
HMGB1 induced the activation of p38MAPK , ERK1/2 and Akt