◀ Back to FGF7
FGF7 — SDC2
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
FGF7
→
Complex of FGF7-SDC2
(directlyIncreases)
Evidence: In general, free heparin/HSPGs sequester FGFs in the extracellular environment and act as FGF antagonists. On the contrary, cellassociated HSPGs can directly activate a signal transduction pathway in response to FGF2 [124], promote FGF2 internalization [125,126], and are required for a correct presentation of FGFs to FGFRs, leading to the formation of productive HSPGs/FGF/FGFR ternary complexes [121].
Text-mined interactions from Literome
Bodo et al., Eur J Cell Biol 1999
(Craniofacial Dysostosis) :
A regulatory
role of
fibroblast growth factor in the expression of decorin, biglycan, betaglycan and
syndecan in osteoblasts from patients with Crouzon 's syndrome
The et al., Mol Cell 1999
:
In contrast to mutants in other HSPG biosynthesis genes, the activity of the
HSPG dependent
FGF and Wingless signaling pathways are not affected in ttv mutants
Olwin et al., J Cell Biol 1992
:
These results suggest that activation of FGF receptors by acidic, basic or Kaposi 's sarcoma
FGF requires simultaneous binding to a
HSPG and the tyrosine kinase receptor
Quarto et al., J Cell Sci 1994
:
It is noteworthy that
HSPG binding protects FGF-2 from denaturation and proteolytic degradation, provides a matrix bound or cell-surface reservoir of this factor for the cells and is
required for the activation of
FGF high-affinity receptors
Coutts et al., Immunol Cell Biol 1995
:
The recent discovery of the
involvement of
heparan sulfate proteoglycans (HSPG) in the activation of
fibroblast growth factor receptors ( FGFR ) has led to an intensification of study of this field
Hartmann et al., Curr Biol 1998
:
Although a number of growth factors bind cell-surface heparan sulphate proteoglycans ( HSPGs ), the role of this interaction is unclear except for
fibroblast growth factor which
requires HSPG binding for signalling