Gene interactions and pathways from curated databases and text-mining

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EGF — NFKBIA

Text-mined interactions from Literome

Banan et al., J Pharmacol Exp Ther 2003 : 2 ) EGF ( 10 ng/ml ) stabilized I-kappaBalpha and prevented both NF-kappaB translocation and activation while protecting monolayers against oxidants
Anest et al., J Biol Chem 2004 : Here we show that EGF treatment of quiescent fibroblast does not induce the classical pathway of NF-kappaB activation through IkappaB kinase (IKK) directed IkappaBalpha phosphorylation
Duncan et al., J Biol Chem 2006 : Furthermore, MSK1/2 control EGF induced IkappaB alpha promoter H3-Ser10 phosphorylation in the absence of elevated transcription
Sethi et al., Oncogene 2007 (Adenocarcinoma...) : By using specific antibodies and IkappaBalpha plasmid, which is mutated at tyrosine 42 to phenylalanine, we show that EGF induced the tyrosine phosphorylation of IkappaBalpha at residue 42 ... Furthermore, EGF receptor kinase inhibitor blocked IkappaBalpha phosphorylation and consequent NF-kappaB activation
Sun et al., Oncogene 1998 : Also, Bapta A/M ( a cell-permeable chelator of intracellular calcium ) blocks EGF induced NF-kappa-B activation and IkappaBalpha degradation, suggesting a requirement of intracellular free Ca2+ for this growth factor response