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CD44 — CTTN

Pathways - manually collected, often from reviews:

• WikiPathways Hepatitis C and Hepatocellular Carcinoma: CD44 → CTTN (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Intact Interaction: Complex of 156 proteins (association, anti tag coimmunoprecipitation) Lau et al., Cell 2012

Text-mined interactions from Literome

Bourguignon et al., J Biol Chem 2004 (Calcium Signaling) : Most important, the PKNgamma-ACC fragment functions as a strong dominant negative mutant that effectively inhibits HA/CD44 mediated PKNgamma phosphorylation of PLCgamma1 and cortactin as well as keratinocyte signaling ( e.g. Ca ( 2+ ) mobilization and cortactin-actin binding ) and cellular functioning ( e.g. cell-cell adhesion and differentiation )
Hill et al., Oncogene 2006 (Breast Neoplasms...) : The mechanistic basis underpinning CD44 promoted transcription of EMS1/cortactin was shown to be dependent upon a NFkappaB mechanism, since pharmacological inhibition of IkappaKinase-2 or suppression of p65 Rel A expression attenuated CD44 induced increases in cortactin mRNA transcript levels
Bourguignon et al., J Neurochem 2007 : Over-expression of the PKN gamma-ACC domain also functions as a dominant negative mutant to block HA/CD44 mediated PKN gamma activation of cortactin and astrocyte migration