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CHUK — MAP3K8

Pathways - manually collected, often from reviews:

• KEGG MAPK signaling pathway: MAP3K8 → CHUK/IKBKB/IKBKG (protein-protein, phosphorylation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: CHUK — MAP3K8 (direct interaction, enzymatic study) Lin et al., Immunity 1999*
• IRef Biogrid Interaction: CHUK — MAP3K8 (physical association, affinity chromatography technology) Lin et al., Immunity 1999*
• MIPS CORUM TNF-alpha/Nf-kappa B signaling complex (RPL6, RPL30, RPS13, CHUK, DDX3X, NFKB2, NFKBIB, REL, IKBKG, NFKB1, MAP3K8, RELB, GLG1, NFKBIA, RELA, TNIP2, GTF2I): TNF-alpha/Nf-kappa B signaling complex (RPL6, RPL30, RPS13, CHUK, DDX3X, NFKB2, NFKBIB, REL, IKBKG, NFKB1, MAP3K8, RELB, GLG1, NFKBIA, RELA, TNIP2, GTF2I) complex (CHUK-DDX3X-GLG1-GTF2I-IKBKG-MAP3K8-NFKB1-NFKB2-NFKBIA-NFKBIB-REL-RELA-RELB-RPL30-RPL6-RPS13-TNIP2) Bouwmeester et al., Nat Cell Biol 2004
• IRef Corum Interaction: Complex of 18 proteins (association, tandem affinity purification) Bouwmeester et al., Nat Cell Biol 2004
• IRef Hprd Interaction: Complex of 290 proteins (in vivo) Bouwmeester et al., Nat Cell Biol 2004
• IRef Hprd Interaction: CHUK — MAP3K8 (in vivo) Lin et al., Immunity 1999*
• IRef Innatedb Interaction: CHUK — MAP3K8 (unknown, -) Lin et al., Immunity 1999*
• IRef Ophid Interaction: CHUK — MAP3K8 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Zhao et al., J Biol Chem 1999 : The essential features of this cascade are that a mitogen activated protein kinase kinase kinase ( MAP3K ) activates an IkappaB kinase (IKK) that site-specifically phosphorylates IkappaB
Waterfield et al., Mol Cell Biol 2004 : Using IKK-deficient murine fibroblasts, we further demonstrate that IKKbeta, but not IKKalpha , is required for Tpl2 activation
Stafford et al., FEBS Lett 2006 : The protein kinase COT/Tpl2 is activated by interleukin-1 (IL-1), TNFalpha and lipopolysaccharide, and its activation by these agonists involves the IkappaB kinase beta (IKKbeta) catalysed phosphorylation of the p105 regulatory subunit