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CA2 — PAF1

Text-mined interactions from Literome

Zardini et al., Therapie 1999 : Chelation of intracellular calcium induced an inhibition of fMLP- or PAF induced [Ca2+ ] i rise and a decrease in O2- production
Bastien et al., J Immunol 1999 : PAF ( 10-7 M ) stimulated increases in intracellular Ca2+ that were consistently higher in the low and medium density B lymphocytes compared with high density cells
Shen et al., Zhongguo Yao Li Xue Bao 1999 : In the presence of egtazic acid 1 mmol.L-1, Pro 10, 20, and 40 mumol.L-1 reduced the Ca2+ release induced by ADP, AA, and PAF , respectively
Shah et al., Biochem Pharmacol 1999 : These results suggest that the curcumin mediated preferential inhibition of PAF- and AA-induced platelet aggregation involves inhibitory effects on TXA2 synthesis and Ca2+ signaling, but without the involvement of PKC
Wang et al., Brain Res 1999 (Calcium Signaling) : In normal physiological solution ( PSS ), PAF induced transient increases in [ Ca2+ ] ( i ) which recovered to baseline values within 200 s. Application of PAF in zero-Ca ( 2+ ) solution caused the peak response to be decreased to a value near 20 % of that recorded in PSS suggesting a primary contribution of Ca ( 2+ ) influx for the [ Ca2+ ] ( i ) increase in PSS
Hermoso et al., Pflugers Arch 2001 : Using the fluorescent indicator fura-2, we measured the effect of PAF on intracellular Ca2+ concentration ([Ca2+]i) in individual ciliated cells
Mooren et al., Int J Sports Med 2001 (Calcium Signaling) : While resting [Ca2+ ] i levels were unchanged, the Ca2+ transient induced N-formyl-methionyl-leucyl phenylalanine ( fMLP ) and platelet activating factor (PAF) were enhanced 1 hour after the test compared to pre-exercise values although fMLP receptor density did not change
Shah et al., Exp Mol Med 2001 : These data suggest that synergistic effect of 5-HT and PAF on human platelet aggregation involves activation of PLC/Ca2+ , COX and MAP kinase pathways
Tsuyuki et al., Biochim Biophys Acta 2002 : As we had found previously that thapsigargin, an endomembrane Ca2+-ATPase inhibitor, induces production of intracellular platelet activating factor (PAF) [ Br. J. Pharmacol. 116 ( 1995 ) 2141 ], we decided to investigate the possible roles of intracellular PAF in nuclear factor (NF)-kappaB activation of thapsigargin stimulated rat peritoneal macrophages
Lu et al., Biol Reprod 2003 (Calcium Signaling) : The L-type calcium channel agonist ( +/- ) BAY K 8644 induced [Ca2+ ] i transients and, PAF and BAY K 8644 each caused mutual heterologous desensitization of each other 's responses
Yue et al., Mol Pharmacol 1992 (Neuroblastoma) : The protein kinase C ( PKC ) activator phorbol 12,13-dibutyrate concentration-dependently inhibited PAF induced Pl metabolism and [Ca2+ ] i mobilization in NCB-20 cells, of NCB-20 cells with pertussis toxin ( PTX ) resulted in a concentration dependent inhibition of PAF induced IP3 production and intracellular Ca2+ release, with a maximal reduction of 66.9 +/- 3.5 % and 63 +/- 6.1 %, respectively, at 300 ng/ml PTX
Alonso et al., Biochim Biophys Acta 1992 : In addition, PCA 4230 inhibited both PAF induced Ca2+ entry and Ca2+ release, behaving as a PAF-antagonist
Tufano et al., J Immunol 1992 : The activation of PAF synthesis by porins as well as its release were dependent on extracellular Ca2+
Mazer et al., J Clin Invest 1992 : The toxins blocked both PAF induced transmembrane uptake of Ca2+ as well as release of Ca2+ from internal stores, and were selective in that activation events after cross linking of surface IgM were not affected
Orallo et al., J Pharm Pharmacol 1992 : PAF did not affect the basal uptake of 45Ca2+ nor that induced by the two vasoconstrictor agents
Gómez-Garre et al., Eur J Pharmacol 1992 : This PAF production was dependent on intra- and extracellular Ca2+
Yeh et al., Life Sci 2005 : In Madin-Darby canine kidney ( MDCK ) cells, the effect of 2-O-methyl PAF , an inactive analogue of platelet activating factor (PAF), on intracellular Ca2+ concentration ([Ca2+]i) was measured by using the Ca2+-sensitive fluorescent dye fura-2
Schaberg et al., Biochem Biophys Res Commun 1991 : PAF increased [Ca2+ ] i in a dose dependent manner ( EC50 = 1 x 10 ( -8 ) M ), whereas lyso-PAF had no effect
Grigoriadis et al., Br J Pharmacol 1991 : Hexanolamine PAF ( 100 nM ), at a concentration equi-effective with PAF ( 1 nM ) for stimulation of O2- generation in macrophages, induced an increase in [Ca2+ ] i which was significantly less than that induced by PAF
Chu et al., Phytother Res 2008 (Myocardial Reperfusion Injury) : PAF ( 10 ( -11 ) m ) significantly increased the intracellular free Ca2+ concentration ([Ca2+]i) and VCF inhibited the changes induced by PAF in single cardiac myocytes
Randriamampita et al., Cell Regul 1991 (Second Messenger Systems) : First, we confirmed that IP3 plays an important role in the initiation of the PAF induced [Ca2+ ] i rise
Sasaki et al., Lipids 1991 : PAF ( 1 microM ) increased H2O2 production in peritoneal macrophages in the presence of extracellular Ca2+ , but H2O2 production was not observed in the absence of extracellular Ca2+
Wood et al., J Biol Chem 1991 : To determine the source of Ca2+, cells were bathed in Ca ( 2+ ) -free medium, where PAF still caused an increase in [ Ca2+ ] i, establishing that the response to PAF arose, at least in part, by release of Ca2+ from internal stores
Pinelis et al., Biull Eksp Biol Med 1991 : This suggests that PAF causes influx of exogenous Ca2+ through the receptor mediated channels as well as releasing Ca2+ from intracellular stores
Shi et al., Neurochem Int 2010 (Alzheimer Disease...) : H2O2 and PAF mediate Abeta1-42 induced Ca2+ dyshomeostasis that is blocked by EGb761
Aepfelbacher et al., Biochim Biophys Acta 1991 : Cholesterol modulates PAF stimulated Ca2 ( + ) -mobilization in monocytic U937 cells
Tatarskiĭ et al., Ter Arkh 1991 (Asthma) : It was shown that platelets of asthmatic patients notwithstanding the disease form are more sensitive to the stimulating action of platelet activating factor (PAF) in aggregation response and intracellular Ca2+ influx induction than platelets of healthy donors
Meng et al., Mol Cell Biochem 1990 : Interestingly, passive Ca2+ binding to cardiac sarcolemma was increased by 40 microM PAF
Emirova et al., Ter Arkh 1990 (Asthma) : It was shown that platelets of asthmatics with the atopic and aspirin-sensitive disease forms are more sensitive to the stimulating action of platelet activating factor (PAF) in aggregation response and intracellular Ca2+ influx induction than platelets of patients suffering mostly from the recurrent bronchopulmonary infections with atopic component ( so-called `` mixed '' asthma ) and more activated than platelets of healthy donors
Diez et al., Br J Pharmacol 1990 : 7. These results suggest that in guinea-pig atria the biphasic inotropic effects of PAF can not be explained through modifications in the slow inward Ca2+ current or in Na'-Ca2+ exchange, but may be related to changes in trans-sarcolemmal Ca2 + entry mediated by specific PAF receptors
O'Flaherty et al., J Biol Chem 1989 : The last two responses, however, failed to occur in cells that were ( a ) calcium depleted, ( b ) treated with high activator concentrations ( which inhibited virtually all PAF binding and PAF induced Ca2+ transients ), or ( c ) treated with PAF 5 min before a PKC activator ( PAF induced rises in cytosolic Ca2+ reversed in less than 5 min )
Bruijnzeel et al., Br J Pharmacol 1989 : BN 52021, at a concentration of 100 microM, completely inhibited Paf induced Ca2+-mobilization and inhibited ZAS induced Ca2+-mobilization by about 50 %
Takayasu et al., Biochem Biophys Res Commun 1989 : Specific platelet activating factor (PAF) antagonists ( CV-6209 and WEB-2086 ) and arachidonic acid ( AA ) cascade blockers ( chlorpromazine, indomethacin, CV-4151 and AA-2414 ) potently inhibited the ET-induced increase in [Ca2+ ] i. Additionally, these compounds inhibited the PAF induced increase in [ Ca2+ ] i
Hwang et al., J Biol Chem 1988 : Mg2+, Ca2+ , and K+ ions potentiated the specific [ 3H ] PAF binding in both systems
Cox et al., Comp Biochem Physiol A Comp Physiol 1985 : Chicken thrombocyte activation by PAF required Ca2+ and appeared to be mediated through a specific receptor for PAF
Nakamura et al., Eur J Pharmacol 1988 : This indicates that the stimulation of macrophages by PAF-acether induced intracellular mobilization of Ca2+, and pretreatment with azelastine reduced the PAF-acether induced increase in [Ca2+ ] i in a dose dependent manner ( IC50 = 16 microM )
Koenderman et al., J Immunol 1989 : Thus, platelet activating factor (PAF) induced a transient increase in [Ca2+ ] i and primed the cells to an enhanced respiratory burst upon subsequent interaction with FMLP
Avdonin et al., Biokhimiia 1985 : The elevation of the cAMP content in platelets after addition of prostaglandin E1, forskolin or papaverine leads to a removal of the PAF and ADP effects on the Ca2+in level
Kawaguchi et al., Biochim Biophys Acta 1986 : Moreover, PAF-acether enhanced changes in cell associated Ca2+
Ryan et al., J Appl Physiol 1988 : It was shown that in bovine pulmonary artery EC [Ca2+ ] i rises in response to platelet activating factor (PAF) and thrombin
Hirafuji et al., Biochem Biophys Res Commun 1988 : It was found that PAF-acether but not lyso PAF-acether induced a rapid and transient increase in [Ca2+ ] i in endothelial cells ... PAF-acether induced rise in [Ca2+ ] i was completely blocked by a specific antagonist, BN 52021
Brock et al., Am J Physiol 1986 : Pretreatment of BAEC with PAF ( 10 ( -8 ) M, 15 min ), but not with other PAF analogues, resulted in a decrease in subsequent PAF stimulated 45Ca2+ efflux, thus suggesting an agonist-specific desensitization
Tuffin et al., Adv Exp Med Biol 1985 : [ 3H ] -Paf-acether binding and its inhibition by unlabelled ( R ) -C18-Paf-acether is independent of buffer Ca2+ within the range 0-5.0 mM
Billah et al., Prostaglandins 1985 : The Ca2+-ionophore A23187, in the presence of Ca2+ , caused an increase in the amount of PAF in amnion tissue disks but PAF did not appear to be released into the incubation medium ... The stimulation of PAF formation by A23187 and Ca2+ was not affected by the addition of indomethacin ... Based on these results it is concluded that PAF can be synthesized in amnion tissue and net production is stimulated by Ca2+
Doyle et al., FEBS Lett 1986 : In addition, PAF induced a rapid efflux of 45Ca2+ from preloaded cells, an effect which was concentration dependent
Kang et al., Biochem J 1994 : PAF binding increased the intracellular free Ca2+ concentration ([Ca2+]i) , indicating functional PAF receptors ... PAF stimulated increase in [Ca2+ ] i was also decreased by 60 % in cells supplemented with C20 : 5 omega 3
Morita et al., J Lipid Mediat Cell Signal 1995 : The effects of platelet activating factor (PAF) on catecholamine ( CA ) release and intracellular free Ca2+ concentration ([Ca2+]i) were studied in cultured bovine adrenal chromaffin cells
Siffert et al., J Clin Invest 1995 (Hypertension) : In analyzing possible differences in signal transduction between the immortalized NT and HT lymphoblasts, we observed that cell stimulation with PAF and somatostatin caused a twofold higher increase in [Ca2+ ] i in HT than in NT cell lines
Columbo et al., J Allergy Clin Immunol 1993 : Brief ( 2-minute ) cell preincubation with 1-acyl-2-acetyl-GPC in the absence of extracellular Ca2+ induced a decrease in the subsequent Ca2+ dependent activation of PAF
Capecchi et al., Clin Pharmacol Ther 1995 : The mathematic analysis of the effects of ciprofloxacin showed that time to maximal activity was between 10.4 hours ( PAF dependent [Ca2+ ] i increase ), and 15 hours ( fMLP induced superoxide anion and chemiluminescence production )
Mazer et al., J Lipid Mediat Cell Signal 1994 : In transformed human B-lymphoblastoid cell lines, PAF increases intracellular Ca2+ concentrations ([Ca2+]i) and induces the expression of the proto-oncogenes c-fos and early growth response gene-2 (EGR2)
Kroegel et al., Am J Respir Cell Mol Biol 1994 : Pretreatment with PMA completely inhibited the PAF induced release of eosinophil peroxidase (EPO) and superoxide anions and the rise in intracellular Ca2+ concentration ([Ca2+]i) , with IC50s of 2 to 10 nM
Lin et al., Biochim Biophys Acta 1994 : PAF induced an immediate and concentration dependent increase in [Ca2+ ] i with an EC50 of 4.75 nM ... The calcium channel blockers diltiazem ( 10 microM ) and verapamil ( 10 microM ) had no effect on the PAF induced increase in [ Ca2+ ] i, but depletion of Ca2+ from the incubation buffer caused a 45.26 % reduction of PAF induced [Ca2+ ] i elevation
Zhou et al., Arch Biochem Biophys 1994 : This loss of PAF receptors was associated with an inhibition of a PAF induced increase in [Ca2+ ] i. Evidence presented in this study suggests that the rapid loss of PAF binding sites from the neutrophil surface is due to PMA induced PAF receptor internalization and/or redistribution of cellular PAF receptors
Kondo et al., Am J Respir Cell Mol Biol 1994 : These data suggest that ( 1 ) a PAF induced increase in [ Ca2+ ] i is mediated via PAF receptors, ( 2 ) PAF causes both transient [ Ca2+ ] i release from intracellular stores through IP3 production and sustained [ Ca2+ ] i influx from extracellular solution, and ( 3 ) Ca2+ influx may be a major pathway of PAF induced increase in [ Ca2+ ] i in cow tracheal epithelium
Barnette et al., Biochem Pharmacol 1994 : Although scalaradial inhibited the mobilization of Ca2+ induced by fMLP, LTB4, and PAF , it did not affect the maximal Ca2+ levels attained with A23187 or thapsigargin
Mangino et al., J Immunol 1993 : PAF below the concentration of 1.0 nM did not significantly increase intracellular Ca2+ in T lymphocytes ... PAF binding slightly increases intracellular free Ca2+ in T lymphocytes and appears to be involved in lymphocyte proliferation in response to soluble plant mitogen and alloantigen
Javors et al., Life Sci 1993 : One of our most significant findings was that pretreatment of platelets with subthreshold concentrations of FAVA produced enhanced PAF induced increase in [Ca2+ ] cyt, suggesting that synergism between the two agonists might play an important role in the physiological response to FAVA
Katnik et al., J Membr Biol 1993 : We investigated PAF induced Ca2+ signaling in HMDMs using the calcium indicator Fura-2, combining single cell ratio fluorimetry and digital video imaging with whole-cell recording techniques
Diserbo et al., Cell Calcium 1995 (Neuroblastoma) : Using the whole-cell voltage-clamp technique, we observe that PAF induces an increase of Ltype Ca2+ current ... However, the effects of La3+, nifedipine and KCl induced depolarization on the PAF induced [Ca2+ ] i increase suggest a minor participation of these voltage gated Ca2+ channels in the response to PAF
Catalán et al., J Cereb Blood Flow Metab 1996 : The effects evoked by endothelins on phosphoinositide metabolism and PAF production were, to a certain extent, dependent on the presence of extracellular Ca2+
Nowak et al., J Lipid Mediat Cell Signal 1996 : The contribution of Ca2+ from intracellular stores to the first PAF induced Ca2+ response was about 1.4-fold lower in comparison with the first fMLP induced Ca2+ response ( 27 +/- 1 vs 37 +/- 6 % ( p < 0.05 )
Tiemann et al., J Reprod Fertil 1996 : Voltage-sensitive calcium channels do not appear to be involved in the influx of extracellular Ca2+ since verapamil had no effect on the PAF induced increase in [ Ca2+ ] i
Packham et al., J Lipid Mediat Cell Signal 1996 : Both DHG and OAG synergistically potentiated PAF induced aggregation of human platelets, but, paradoxically, concurrently inhibited the PAF induced increase in intracellular Ca2+ ( [ Ca2+ ] i ) : potentiation decreased upon incubation with DAGs before PAF addition ... Effects of DHG and OAG on PAF induced increases in [Ca2+ ] i in rabbit platelets followed a similar pattern ; thus, with rabbit platelets, inhibition of the [Ca2+ ] i increase may at least partially account for inhibition of PAF induced aggregation by exogenous DAGs
Dohi et al., J Dent Res 1997 (Second Messenger Systems) : Acetylcholine and norepinephrine increased both the PAF production and liberation of [ 14C ] arachidonic acid from cells pre labeled with [ 14C ] arachidonic acid in the presence of Ca2+ in the medium
Gamaley et al., Free Radic Biol Med 1998 : Furthermore, in the presence of quinidine, a blocker of Ca2+ dependent K+ conductance fMLP and PAF caused only prolonged depolarization while the effect of O2.- was reduced to a minimum
Nilius et al., Verhandelingen - Koninklijke Academie voor Geneeskunde van België 1998 (Second Messenger Systems) : Ca2+ signals in endothelial cells play the key role in the release of NO, prostacyclin ( PGI2 ), platelet activating factor (PAF) , von Willebrand factor (vWF), tissue plasminogen activator (tPA) and tissue factor pathway inhibitor (TFPI)
Song et al., Zhongguo Yao Li Xue Bao 1996 : Although LPS did not increase intracellular Ca2+ of PMo, intracellular Ca2+ was necessary for PAF release from rat PMo stimulated by LPS