Kern et al., Eur J Biochem 1993
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In the presence of Ca2+ and Mg2+ the affinity of collagen IV for alpha 1 beta 1 was four-times higher than for alpha 2 beta 1
Genersch et al., J Mol Med (Berl) 1996
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In cell adhesion assays performed in the presence of divalent cations MTLn3 and A431 cells exhibited the typical behavior described for integrin dependent matrix adhesion : Mn2+ enhanced binding to collagen IV and fibronectin whereas Ca2+ inhibited adhesion to collagen IV but not to fibronectin
Ambili et al., Indian J Biochem Biophys 1997
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Zymographic and radiolabelled substrate digestion studies at different pH and in presence of different cations showed that the activated form of this gelatinase is a Ca2+ dependent neutral matrix metalloproteinase capable of cleaving collagen I and collagen IV