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ADCY7 — IL1A

Text-mined interactions from Literome

Rodan et al., J Immunol 1990 (Bone Resorption...) : Although IL-1 had no effect on PGE2 synthesis, both IL-1 alpha and IL-1 beta enhanced PGE2 stimulation of adenylate cyclase two- to four-fold in a dose dependent manner ... IL-1 did not enhance basal adenylate cyclase or stimulation by parathyroid hormone, isoproterenol, or forskolin
Schettini et al., Endocrinology 1990 : The effects of IL1 on adenylate cyclase activity and calcium fluxes were reversed by preincubation of the monokine with its polyclonal antibody, thus confirming the specificity of the effects
Făgăraşan et al., Proc Natl Acad Sci U S A 1989 (Pituitary Neoplasms) : This suggests that IL-1 does not induce adenylate cyclase and that forskolin causes the secretion of beta-endorphin by a mechanism independent of cAMP
Fukuoka et al., Endocrinology 1989 : IL-1 also significantly reduced intra- and extracellular cAMP accumulation by the cells in response to forskolin ( 50, 150 microM ) by 28-46 %, indicating that IL-1 can directly inhibit adenylate cyclase activity