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PPARA — PPARGC1A
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
PPARA
—
PPARGC1A
(direct interaction, pull down)
Vega et al., Mol Cell Biol 2000*
-
IRef Hprd Interaction:
Complex of 111 proteins
(in vivo)
Surapureddi et al., Proc Natl Acad Sci U S A 2002
-
IRef Hprd Interaction:
PPARA
—
PPARGC1A
(in vitro)
Vega et al., Mol Cell Biol 2000*
-
IRef Hprd Interaction:
PPARA
—
PPARGC1A
(in vivo)
Vega et al., Mol Cell Biol 2000*
-
IRef Hprd Interaction:
PPARA
—
PPARGC1A
(two hybrid)
Vega et al., Mol Cell Biol 2000*
-
IRef Ophid Interaction:
PPARA
—
PPARGC1A
(aggregation, confirmational text mining)
Vega et al., Mol Cell Biol 2000*
-
IRef Ophid Interaction:
PPARA
—
PPARGC1A
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Hsieh et al., FASEB J 2006
(Hemorrhage...) :
PGC-1alpha ( peroxisome proliferator activated receptor [ PPARgamma] coactivator-1alpha )
activates PPARalpha and mitochondrial transcription factor A ( Tfam ), which regulate proteins, fatty acid and ATP metabolism ( i.e., FAT/CD36, MCAD, and COX I )
Cha et al., Proc Natl Acad Sci U S A 2006
:
PGC-1alpha also
increased the expression of ERRalpha,
PPARalpha , and enzymes that support mitochondrial fatty acid oxidation, ATP synthesis, and thermogenesis, apparently mediated by an increased expression of UCP3
Hondares et al., Biochem Biophys Res Commun 2007
:
PPARdelta, but not
PPARalpha ,
activates PGC-1alpha gene transcription in muscle