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HDAC4 — IL2
Text-mined interactions from Literome
Matsuoka et al., Biochem Pharmacol 2007
:
Disruption of
HDAC4/N-CoR complex by histone deacetylase inhibitors
leads to inhibition of
IL-2 gene expression ... We therefore focused on the
role of
HDAC4/N-CoR complex in the transcriptional regulation of
IL-2 ... Here, we report that
HDAC4 plays an essential role in
IL-2 promoter activation, and that the formation of the HDAC4/N-CoR complex, which is closely related to HDAC4-enzymatic activity, might be involved in HDAC inhibitor mediated inhibition of IL-2 gene expression
Nayak et al., J Biol Chem 2009
:
Sumoylation of the transcription factor NFATc1 leads to its subnuclear relocalization and
interleukin-2 repression by
histone deacetylase
Rehni et al., Naunyn Schmiedebergs Arch Pharmacol 2012
(Opioid-Related Disorders...) :
The present study has been designed to investigate the effect of selective inhibitors of
histone deacetylase and/or N-acetyl-Asp-Glu-Val-Asp-al ( Ac-DEVD-CHO ), a selective
interleukin-1ß converting enzyme
inhibitor , on the development of naloxone induced opioid withdrawal syndrome both in vitro and in vivo and the effect of histone deacetylase inhibition on histone H3 acetylation in brain