Okazaki et al., Proc Natl Acad Sci U S A 2001
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These results show that PD-1 can inhibit BCR signaling by recruiting SHP-2 to its phosphotyrosine and dephosphorylating key signal transducers of BCR signaling
Haas et al., J Immunol 2009
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Reducing CD19 expression in CD21/35 ( -/- ) mice normalized BCR induced calcium responses, PD-1 induction, and PPS-3-specific IgG3 responses and restored protection during S. pneumoniae infection