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CHUK — IRAK1
Pathways - manually collected, often from reviews:
-
BioCarta nf-kb signaling pathway:
LPS/TLR4/TLR4/MYD88/IRAK/TRAF6 complex (TLR4-MYD88-IRAK1-TRAF6)
→
IKK-alpha/MEKK1/NIK complex (CHUK-MAP3K1-MAP4K4)
(modification, activates)
-
BioCarta nf-kb signaling pathway:
IL-1/IL-1R/MYD88/IRAK/TRAF6 complex (IL1A-IL1R1-MYD88-IRAK1-TRAF6)
→
IKK-alpha/MEKK1/NIK complex (CHUK-MAP3K1-MAP4K4)
(modification, activates)
-
NCI Pathway Database p75(NTR)-mediated signaling:
NGF (dimer)/p75(NTR)/TRAF6/RIP2/IRAK/p62/Atypical PKCs complex (NGF-NGFR-TRAF6-RIPK2-IRAK1-SQSTM1-PRKCI_PRKCZ)
→
IKK complex complex (CHUK-IKBKB-IKBKG)
(modification, activates)
Hamanoue et al., Mol Cell Neurosci 1999, Wooten et al., J Biol Chem 2001, Khursigara et al., J Neurosci 2001, Mamidipudi et al., J Biol Chem 2002, Yeiser et al., J Neurosci 2004, Carter et al., Science 1996
Evidence: mutant phenotype, reporter gene, other species
-
Reactome Reaction:
CHUK
→
IRAK1
(reaction)
Wang et al., Nature 2001, Wu et al., Nat Cell Biol 2006, Adhikari et al., Oncogene 2007, Windheim et al., Mol Cell Biol 2008, Conze et al., Mol Cell Biol 2008, Arch et al., Genes Dev 1998
-
Reactome Reaction:
CHUK
→
IRAK1
(indirect_complex)
Wu et al., Nat Cell Biol 2006, Windheim et al., Mol Cell Biol 2008, Conze et al., Mol Cell Biol 2008
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Manna et al., J Biol Chem 2005
:
The data suggest that IL-8 induced NF-kappaB activation proceeds through a TRAF2 independent but TRAF6 dependent pathway, followed by recruitment of
IRAK and
activation of
IKK
Windheim et al., Mol Cell Biol 2008
:
Our data suggest a model in which the recruitment of the NEMO-IKK complex to K63-pUb-IRAK1 and the recruitment of the TAK1 complex to TRAF6 facilitate the TAK1 catalyzed
activation of
IKK by the
TRAF6-IRAK1 complex