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GATA3 — IFNG

Text-mined interactions from Literome

Ferber et al., Clin Immunol 1999 : We now show that ectopic expression of GATA-3 in developing Th1 cells significantly inhibits IFN-gamma , as well as enhancing IL-4 and IL-5 production ... Furthermore, GATA-3 inhibits production of IFN-gamma by developing Th1 cells in the complete absence of IL-4
Grogan et al., Immunity 2001 : Although T cells transcribed both IFN-gamma and IL-4 within hours in a Stat4-/Stat6 independent manner, neither T-bet nor GATA-3 was induced optimally without Stat signals, and polarized cytokine expression was not sustained
Yoh et al., J Am Soc Nephrol 2003 (Autoimmune Diseases...) : GATA-3 overexpression in Yaa mice led to simultaneously elevated Th2 Ig ( IgG1 ) and decreased Th1 Ig ( IgG2a and IgG3 ) production and serum IFN-gamma levels
Samson et al., Immunity 2003 (Listeriosis) : GATA-3 promotes maturation, IFN-gamma production, and liver-specific homing of NK cells
Kaminuma et al., FEBS Lett 2004 : A reduction of GATA-3 using RNA interference technology enhanced, whereas overexpression of GATA-3 suppressed IFN-gamma mRNA expression ... GATA-3 mediated down-regulation of IFN-gamma was achieved through the inhibition of its promoter/enhancer activity ... The effect of GATA-3 on IFN-gamma promoter was lost upon removal of the region encompassing -257 to -172
Yi et al., J Med Food 2005 (Herpesviridae Infections) : Allitridin could up-regulate the expression of T-bet and IFN-gamma and inhibit the expression of GATA-3 and IL-10 in MCMV infected mice, indicating a Th1 dominant state, which should enhance the specific cellular immune reactions against cytomegalovirus ( CMV ) and be helpful for clearance of CMV from the host
Nasta et al., Immunology 2006 : T-bet and GATA-3 , indeed, through chromatin remodelling allow transcriptional activation of Ifngamma and Th2 cytokine ( Il4, Il5, Il13 ) genes, respectively
Yagi et al., Immunity 2010 : The transcription factor GATA3 actively represses RUNX3 protein regulated production of interferon-gamma ... GATA3 overexpression blocked Runx3 mediated Eomes induction and IFN-gamma production, and GATA3 protein physically interacted with Runx3 protein