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HMGB4 — IL8
Text-mined interactions from Literome
Yu et al., Shock 2006
:
However, in human embryonic kidney 293 cells transfected with TLR2 or TLR4,
HMGB1 effectively
induces IL-8 release only from TLR2 overexpressing cells
García-Arnandis et al., Arthritis Res Ther 2010
(MAP Kinase Signaling System...) :
In OA synoviocytes,
HMGB1 alone at concentrations of 15 or 25 ng/ml did not
affect the production of IL-6,
IL-8 , CCL2, CCL20, MMP-1 or MMP-3, but in the presence of IL-1ß, a significant potentiation of protein and mRNA expression, as well as MMP activity was observed