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CTNNB1 — STAT3
Text-mined interactions from Literome
Kawada et al., Cancer Res 2006
(Colorectal Neoplasms...) :
In an in vitro study using a human colon cancer cell line, SW480, inhibition of
STAT3 by dominant negative STAT3 or the Janus kinase inhibitor, AG490,
induced translocation of
beta-catenin from the nucleus to the cytoplasm or membrane ... Luciferase assays revealed that
STAT3 inhibition
resulted in significant suppression of
beta-catenin/T-cell factor transcription in association with significant inhibition of cell proliferation ( P < 0.05 ) ... These findings suggest that in colorectal cancer,
STAT3 activation is
involved in the nuclear accumulation of
beta-catenin , resulting in poor patient survival
Yan et al., Cancer Lett 2008
(Carcinoma, Squamous Cell...) :
Transfected
beta-catenin induced
STAT3 transcriptional activity dose-dependently, and also enhanced STAT3 mRNA and protein levels
Wang et al., Hepatogastroenterology 2011
(Carcinoma, Hepatocellular...) :
After siRNA directed against STAT3 was transfected into HepG2 cells,
STAT3 protein expression was decreased at 72 and 96h and
beta-catenin , GSK-3beta and p-GSK-3beta protein expression all
increased at 72h and decreased at 96 h after transfection