◀ Back to LEP
IRS2 — LEP
Pathways - manually collected, often from reviews:
-
Reactome Reaction:
IRS2
→
LEP
(reaction)
Duan et al., J Biol Chem 2004, Li et al., Mol Endocrinol 2007
-
Reactome Reaction:
IRS2
→
LEP
(indirect_complex)
Szanto et al., Proc Natl Acad Sci U S A 2000, Martín-Romero et al., Cell Immunol 2001, Duan et al., J Biol Chem 2004, Li et al., Mol Endocrinol 2007, Hill et al., J Clin Invest 2008, Buettner et al., Nat Med 2008, Bjørbaek et al., J Biol Chem 1997
Text-mined interactions from Literome
Carvalheira et al., Biol Chem 2003
:
This phenomenon parallels the
leptin induced tyrosine phosphorylation of STAT3, STAT5b, IRS-1 and
IRS-2
Duan et al., J Biol Chem 2004
:
Here we report that SH2-B, a JAK2 interacting protein, promotes activation of the PI 3-kinase pathway by recruiting insulin receptor substrate 1 (IRS1) and
IRS2 in
response to
leptin ... Consequently, SH2-B dramatically enhanced
leptin stimulated tyrosine phosphorylation of IRS1 and
IRS2 in HEK293 cells stably expressing LRb, thus promoting association of IRS1 and IRS2 with the p85 regulatory subunit of PI 3-kinase and phosphorylation and activation of Akt
Benomar et al., Biochem J 2005
:
Furthermore,
leptin or insulin pre-treatment
increased basal PI3K activity and IRS-1 or
IRS-2 association with p85 and abolished acute insulin or leptin effect, in addition to the down-regulation of IRS-1 and IRS-2
Ren et al., Cell Metab 2005
(Body Weight...) :
Leptin stimulated activation of hypothalamic JAK2 and phosphorylation of hypothalamic STAT3 and
IRS2 were significantly impaired in SH2-B ( -/- ) mice
Duan et al., Zhong Nan Da Xue Xue Bao Yi Xue Ban 2010
(Obesity) :
SH2B1 dramatically enhanced the
leptin stimulated tyrosine phosphorylation of JAK2 and
IRS2 in HEK293 cells stably expressing LRb ( HEK239 ( LRb ) ) ...
Leptin stimulated activation of hypothalamic JAK2 and phosphorylation of hyphothalamic
IRS2 were significantly impaired in SH2B1 ( -/- ) mice
Nazarians-Armavil et al., Mol Endocrinol 2013
:
Neuronal insulin resistance, as assessed by attenuated Akt phosphorylation, blocked
leptin mediated signal transduction and agouti related peptide, urocortin-2, IRS1,
IRS2 , and insulin receptor synthesis
Kellerer et al., Diabetologia 1997
:
Since we have also detected
leptin stimulated tyrosine phosphorylation of JAK-2 and
IRS-2 in C2C12 myotubes it can be assumed that leptin activates JAK-2 which induces tyrosine phosphorylation of IRS-2 leading to activation of PI-3 kinase