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IFNG — JUN
Pathways - manually collected, often from reviews:
-
BioCarta the 41bb-dependent immune response:
c-JUN (JUN)
→
IFN-gamma (IFNG)
(transcription, collaborate)
-
NCI Pathway Database Downstream signaling in naïve CD8+ T cells:
JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3)
→
IFN-gamma (IFNG)
(transcription, activates)
Curtsinger et al., J Exp Med 2003, Curtsinger et al., J Immunol 2005, Teixeira et al., J Immunol 2005, Campbell et al., Transplantation 1996
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database ATF-2 transcription factor network:
JUN/ATF2 complex (JUN-ATF2)
→
IFN-gamma (IFNG)
(transcription, activates)
Penix et al., J Biol Chem 1996*
Evidence: assay, physical interaction
-
NCI Pathway Database Downstream signaling in naïve CD8+ T cells:
JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3)
→
IFN-gamma (IFNG)
(transcription, activates)
Curtsinger et al., J Immunol 2005, Campbell et al., Transplantation 1996
Evidence: mutant phenotype, physical interaction, other species
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Zhang et al., J Immunol 1999
:
T cell proliferation and production of IL-2, IL-4, and
IFN-gamma induced by both CD3 and CD3/CD28 ligation and the nuclear expression of the
c-Jun and ATF-2 proteins are each blocked by the p38 MAPK inhibitor SB203580
Seppänen et al., Oncol Res 1998
(Adenocarcinoma...) :
In the present study, we have investigated the
effects of
interferons-alpha (IFN-alpha) and -gamma ( IFN-gamma ), interleukin-10 (IL-10) and -13 ( IL-13 ), transforming growth factor-beta1 ( TGF-beta1 ), granulocyte-macrophage colony stimulating factor ( GM-CSF ), and tumor necrosis factor-alpha (TNF-alpha) on cell proliferation and induction of transcription factors
AP-1 and NF-kappaB in UM-EC-3 human endometrial adenocarcinoma cells and UT-OC-5 ovarian carcinoma cells in vitro
Wang et al., Hypertension 1999
(MAP Kinase Signaling System) :
Tumor necrosis factor-alpha (TNF-alpha) alone can
induce extracellular signal regulated kinase ( ERK ), p38 MAPK, and
c-Jun N-terminal kinase activity in a rapid and transient manner, whereas
interferon-gamma (IFN-gamma) can induce only ERK
Hamada et al., Toxicology 2000
:
However, NF-kappaB was increased at 3 h while AP-1 ( Jun B and Jun D ) and CREB were increased at 15 h. Co-stimulation of 12j cells with
rMu-IFN-gamma + Be
increased the levels of NF-KB in 12j cell nuclei at 3 h, and the levels of
AP-1 and CREB at 15 h, however, only Jun B was increased
Kim et al., J Immunol 2000
:
EMSA using an AP-1-specific oligonucleotide demonstrated that
IFN-gamma or LPS treatment
increased the
AP-1 binding activity
Nakahira et al., J Immunol 2002
:
These results show that STAT4 up-regulates
AP-1 mediated
IFN-gamma promoter
activation without directly binding to the promoter sequence, providing a mechanistic explanation for IL-12/IL-18 induced synergistic enhancement of IFN-gamma gene expression
Kaminuma et al., FEBS Lett 2002
:
Vav induced activation of the human
IFN-gamma gene promoter is
mediated by upregulation of
AP-1 activity
Yasumoto et al., J Biol Chem 1992
(Stomach Neoplasms) :
Moreover, gel retardation analyses revealed that TNF alpha and
IFN gamma synergistically
induced the binding of NF-kB like as well as
AP-1 like proteins bound to these sites
Jana et al., Free Radic Biol Med 2005
:
All three cytokines alone induced the activation of
AP-1 while IL-1beta and TNF-alpha but not
IFN-gamma induced the activation of NF-kappaB ... Although IL-1beta and
IFN-gamma alone
induced the activation of
AP-1 , the combination of these two cytokines ( IL-IF ) markedly inhibited the activation of AP-1
Yamada et al., J Urol 2005
(Urinary Bladder Neoplasms) :
Although LPS and IFN-gamma alone marginally activated nuclear factor (NF)-kappaB but not AP-1, LPS plus
IFN-gamma augmented NF-kappaB and
AP-1
Sheu et al., Food Chem Toxicol 2006
(Glomerulonephritis) :
Electrophoretic mobility shift assay experiments demonstrated that CLA ( 100 microM ) dramatically reduced activation of nuclear factor-kappaB (NF-kappaB),
activator protein-1 (AP-1) and cAMP response element binding protein ( CREB )
induced by
LPS/IFN-gamma ... Electrophoretic mobility shift assay experiments demonstrated that CLA ( 100 microM ) dramatically reduced activation of nuclear factor-kappaB (NF-kappaB),
activator protein-1 (AP-1) and cAMP response element binding protein ( CREB )
induced by
LPS/IFN-gamma
Bae et al., Planta Med 2006
:
Electrophoretic mobility shift assays revealed that ginsenoside Rh2 significantly inhibited the
LPS/IFN-gamma induced
AP-1 DNA binding activity, while it enhanced the protein binding to CRE sequences
Hu et al., Immunity 2006
(Arthritis...) :
IFN-gamma suppressed the activity of CREB and
AP-1 , transcription factors that induce IL-10 expression and are regulated in part by MAPKs and GSK3
Gough et al., J Biol Chem 2007
(MAP Kinase Signaling System) :
Herein we have shown that
IFNgamma rapidly
activated AP-1 DNA binding that required c-Jun but was independent of JAK1 and STAT1 ...
IFNgamma induced c-Jun phosphorylation and
AP-1 DNA binding required the MEK1/2 and ERK1/2 signaling pathways, whereas the JNK1/2 and p38 mitogen activated protein kinase pathways were dispensable ... Thus,
IFNgamma induced JAK1- and STAT1 independent activation of the ERK mitogen activated protein kinase pathway, phosphorylation of c-Jun, and activation of
AP-1 DNA binding, which are important for the induction of a subset of ISGs
Deng et al., Arterioscler Thromb Vasc Biol 2007
:
IFNgamma blocked
C-Jun and C/EBPbeta but not C-Fos or p50 NF-kappaB binding as determined by in vitro binding assays and chromatin immunoprecipitation assay
Liu et al., J Ethnopharmacol 2007
(Edema...) :
To clarify the mechanisms involved, methanol extracts from fruiting body were found to inhibit the phosphorylation of extracellular signal regulated protein kinases ( ERK ),
c-Jun NH2-terminal protein kinases (JNK) and signal transducer and activator of transcription-1 ( STAT-1 )
induced by
LPS/IFN-gamma
Pedra et al., Infect Immun 2008
(Ehrlichiosis) :
Here we show that
c-Jun NH2-terminal kinase 2 (JNK2) inhibits
IFN-gamma production during A. phagocytophilum infection
Nishida et al., Am J Physiol Gastrointest Liver Physiol 2008
:
Furthermore, LY294002 suppressed both IL-1beta- and TNF-alpha induced NF-kappaB activation and IL-1beta-, TNF-alpha-, and
IFN-gamma induced
activated protein-1 (AP-1) activation
Seppänen et al., Acta Obstet Gynecol Scand 2008
(Carcinoma, Endometrioid...) :
We were able to show that
IFN-gamma , TGF-beta(1) and TNF-alpha all
increased the binding activity of transcription factor
AP-1 ( AP-1 )
Wu et al., Br J Pharmacol 2009
:
Effects of tripterine were investigated on endothelial barrier function, inducible nitric oxide synthase (iNOS) expression, nicotinamide adenine dinucleotide phasphate ( NADPH ) oxidase activity, 3-nitrotyrosine formation, protein phosphatase type 2A (PP2A) activity,
activation of extracellular regulated kinase (ERK),
c-Jun terminal kinase (JNK) and Janus kinase ( Jak2 ), and degradation of IkappaB in microvascular endothelial cells exposed to pro-inflammatory stimulus [ lipopolysaccharide (LPS) +
interferon gamma (IFNgamma) ] and on vascular permeability in air pouches of mice injected with LPS + IFNgamma
Do et al., J Nutr Biochem 2010
(Brain Neoplasms...) :
In addition, fucoidan inhibited TNF-alpha- and
IFN-gamma induced
AP-1 , IRF-1, JAK/STAT and p38 mitogen activated protein kinase ( MAPK ) activation and induced scavenger receptor B1 (SR-B1) expression
Wallet et al., Cell Immunol 2010
(Inflammation) :
IFNgamma primed, HMW-HA activated macrophages produced elevated levels of TNF and secreted the TH1 cytokine IL-12p70, while
IFNgamma suppressed HMW-HA induced secretion of the regulatory cytokine IL-10 and activation of the transcription factor
c-Jun
Jung et al., Int Immunopharmacol 2010
:
Inhibition of these inflammatory mediators appears to be at the transcriptional level, since diosgenin decreased
LPS/IFN-gamma induced NF-kappaB and
AP-1 activity
de Wit et al., Exp Hematol 1996
:
We conclude that the
effects of
IFN-gamma on the expression of the transcription factors
AP-1 and NF-kappa B may be important for the modulatory effects of IFN-gamma on the cytokine expression in activated human monocytes
Barbulescu et al., J Immunol 1998
:
These data suggest that both
AP-1 and STAT4 are
required for IL-12 dependent
IFN-gamma promoter activity, whereas IL-18 causes direct activation via AP-1