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ABCB1 — JUN
Text-mined interactions from Literome
Ratnasinghe et al., Anticancer Res 2001
(Breast Neoplasms) :
We hypothesized that increased prostaglandin production by Cox-2 induces PKC and the expression of transcriptional factor
c-Jun , which in turn,
induces the expression of
MDR1/Pgp170
Hatle et al., Mol Cell Biol 2007
(Breast Neoplasms) :
The induction of
ABCB1 gene expression is
mediated by increased levels of
c-Jun due to an impaired degradation of this transcription factor in the absence of MCJ ... Thus, MCJ is required in these cells to prevent
c-Jun mediated expression of
ABCB1 and maintain drug response
Roy et al., Cancer Chemother Pharmacol 2010
(Carcinoma, Hepatocellular...) :
Further studies revealed the
involvement of
AP-1 in the celecoxib induced downregulation of
MDR1 expression
Takano et al., Biochem Pharmacol 2010
(Carcinoma, Renal Cell...) :
Moreover, increased transcription activity of
c-Jun by the JNK activation
contributed to the down-regulation of
MDR1 , thus indicating a central role of JNK signalling to suppress P-gp level in 5-Aza treated Caki-1 cells
Nishanth et al., Eur J Pharmacol 2010
(Carcinoma, Hepatocellular...) :
Further studies reveal the involvement of NF-?B and
AP-1 in the C-PC
induced down regulation of
MDR1
Fang et al., Anat Rec (Hoboken) 2012
(Carcinoma, Hepatocellular...) :
Our results demonstrated that mda-7/IL-24 could restore the drug sensitivity through the downregulation of
MDR1 , MRP1, and LRP expression, as well as the transcriptional
activation of
AP-1 and NF-?B and effectively reverse MDR
Xia et al., J Biol Chem 2013
(Mammary Neoplasms, Animal) :
Activated
c-Jun bound to the promoter regions of the MDR1 gene and
promoted the expression of
MDR1
Choi et al., Evidence-based complementary and alternative medicine : eCAM 2013
:
Consistently, overexpression of JNK1,
c-Jun , or c-Fos
inhibited YB-1 dependent
MDR1 expression and reduced viabilities in MCF-7/Dox cells