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CCL4 — IL10
Text-mined interactions from Literome
Wang et al., J Immunol 1999
:
IL-4,
IL-10 , IFN-gamma, and IL-18 primarily
inhibited MIP-1beta secretion and also weakly suppressed MIP-1alpha secretion
Olszyna et al., J Infect Dis 2000
(Endotoxemia) :
Sixteen healthy subjects were intravenously injected with lipopolysaccharide (LPS), once with placebo and once with recombinant human interleukin (IL)-10 ( 25 microgram/kg ), to determine the
effect of
IL-10 on LPS induced production of macrophage inflammatory protein (MIP)-1alpha,
MIP-1beta , and monocyte chemoattractant protein (MCP)-1
Lapinet et al., Infect Immun 2000
(Meningitis, Meningococcal) :
In line with its downregulatory effects on neutrophil derived proinflammatory cytokines,
IL-10 potently
inhibited TNF-alpha, IL-1beta, IL-8, and
MIP-1beta production triggered by OMV
Tamassia et al., Int Immunol 2008
(Sepsis...) :
Consistent with the presence of a fully functional IL-10R, modulation of LPS induced CXCL8,
CCL4 , tumour necrosis factor-alpha and IL-1ra gene expression was also rapidly
induced by
IL-10 in septic, but not normal, neutrophils