◀ Back to MYC
MAX — MYC
Pathways - manually collected, often from reviews:
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OpenBEL Selventa BEL large corpus:
MYC
→
Complex of HIF1A-MAX
(decreases, HIF1A/MAX Activity)
Evidence: A recent study suggests another mechanism by which HIF1? inhibits MYC function through binding MAX and thereby displacing MYC4,48.
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OpenBEL Selventa BEL large corpus:
MYC
→
Complex of MAX-MNT
(decreases, MAX/MNT Activity)
Evidence: hetero-dimerization of MAX with other HLH-LZ proteins, such as MAD, Mxi-1 and Mnt, which are antagonists of c-MYC-induced transformation
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OpenBEL Selventa BEL large corpus:
MYC
→
Complex of MAX-MXD1
(decreases, MAX/MXD1 Activity)
Evidence: hetero-dimerization of MAX with other HLH-LZ proteins, such as MAD, Mxi-1 and Mnt, which are antagonists of c-MYC-induced transformation
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BioCarta overview of telomerase protein component gene htert transcriptional regulation:
Max/c-MYC complex (MAX-MYC)
→
TERT
(transcription, activates)
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KEGG Pathways in cancer:
Complex of MAX-MYC
→
PIAS1/PIAS2/PIAS3/PIAS4
(protein-protein, inhibition)
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KEGG Pathways in cancer:
Complex of MAX-MYC
→
CKS1B
(gene expression, expression)
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KEGG Small cell lung cancer:
Complex of MAX-MYC
→
Complex of CCND1-CDK4-CDK6
(gene expression, expression)
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KEGG Small cell lung cancer:
Complex of MAX-MYC
→
CKS1B
(gene expression, expression)
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KEGG Small cell lung cancer:
Complex of MAX-MYC
→
PIAS1/PIAS2/PIAS3/PIAS4
(protein-protein, inhibition)
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NCI Pathway Database C-MYC pathway:
MYC/Max/P-TEFb complex (MYC-MAX)
→
MYC/Max complex (MYC-MAX)
(modification, collaborate)
Eberhardy et al., J Biol Chem 2001, Eberhardy et al., J Biol Chem 2002*
Evidence: physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional repression:
MIZ-1 (ZBTB17)
→
MYC/Max/MIZ-1/DNMT3A/GFI1 complex (MYC-MAX-ZBTB17-DNMT3A-GFI1)
(transcription, activates)
Claassen et al., Proc Natl Acad Sci U S A 2000, Seoane et al., Nature 2002, Wu et al., Oncogene 2003, Brenner et al., EMBO J 2005, Liu et al., Oncogene 2010
Evidence: mutant phenotype, assay, reporter gene, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional repression:
ZO2 (TJP2)
→
MYC/Max/MIZ-1/ZO2 complex (MYC-MAX-ZBTB17-TJP2)
(modification, collaborate)
Huerta et al., Mol Biol Cell 2007
Evidence: physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional repression:
ZO2 (TJP2)
→
MYC/Max/MIZ-1 complex (MYC-MAX-ZBTB17)
(modification, collaborate)
Huerta et al., Mol Biol Cell 2007
Evidence: physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional repression:
MYC/Max/MIZ-1/ZO2 complex (MYC-MAX-ZBTB17-TJP2)
→
MYC/Max/MIZ-1 complex (MYC-MAX-ZBTB17)
(modification, collaborate)
Huerta et al., Mol Biol Cell 2007
Evidence: physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional repression:
MYC/Max/NF-Y complex (MYC-MAX-NFYA-NFYC-NFYB)
→
NF-Y complex (NFYA-NFYB-NFYC)
(modification, collaborate)
Izumi et al., J Cell Sci 2001
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional repression:
MYC/Max/NF-Y complex (MYC-MAX-NFYA-NFYC-NFYB)
→
MYC/Max complex (MYC-MAX)
(modification, collaborate)
Izumi et al., J Cell Sci 2001
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional repression:
NF-Y complex (NFYA-NFYB-NFYC)
→
MYC/Max complex (MYC-MAX)
(modification, collaborate)
Izumi et al., J Cell Sci 2001
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional repression:
HDAC3 (HDAC3)
→
MYC/Max/HDAC3 complex (MYC-MAX-HDAC3)
(modification, collaborate)
Kurland et al., Cancer Res 2008
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional repression:
HDAC3 (HDAC3)
→
MYC/Max complex (MYC-MAX)
(modification, collaborate)
Kurland et al., Cancer Res 2008
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional repression:
MYC/Max/HDAC3 complex (MYC-MAX-HDAC3)
→
MYC/Max complex (MYC-MAX)
(modification, collaborate)
Kurland et al., Cancer Res 2008
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional activation:
PIM1 (PIM1)
→
MYC/Max/PIM1 complex (MYC-MAX-PIM1)
(modification, collaborate)
Zippo et al., Nat Cell Biol 2007
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional activation:
PIM1 (PIM1)
→
MYC/Max complex (MYC-MAX)
(modification, collaborate)
Zippo et al., Nat Cell Biol 2007
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional activation:
MYC/Max/PIM1 complex (MYC-MAX-PIM1)
→
MYC/Max complex (MYC-MAX)
(modification, collaborate)
Zippo et al., Nat Cell Biol 2007
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database C-MYC pathway:
TRRAP/TIP60 complex (TRRAP-KAT5)
→
MYC/Max/TRRAP/TIP60/TIP49A/TIP49B/BAF53 complex (MYC-MAX-ACTL6A-RUVBL1-RUVBL2-TRRAP-KAT5)
(modification, collaborate)
Wood et al., Mol Cell 2000, Frank et al., EMBO Rep 2003
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database C-MYC pathway:
TRRAP/TIP60 complex (TRRAP-KAT5)
→
MYC/Max complex (MYC-MAX)
(modification, collaborate)
Wood et al., Mol Cell 2000, Frank et al., EMBO Rep 2003
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database C-MYC pathway:
BAF53 (ACTL6A)
→
MYC/Max/TRRAP/TIP60/TIP49A/TIP49B/BAF53 complex (MYC-MAX-ACTL6A-RUVBL1-RUVBL2-TRRAP-KAT5)
(modification, collaborate)
Wood et al., Mol Cell 2000, Frank et al., EMBO Rep 2003
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database C-MYC pathway:
BAF53 (ACTL6A)
→
MYC/Max complex (MYC-MAX)
(modification, collaborate)
Wood et al., Mol Cell 2000, Frank et al., EMBO Rep 2003
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database C-MYC pathway:
MYC/Max/TRRAP/TIP60/TIP49A/TIP49B/BAF53 complex (MYC-MAX-ACTL6A-RUVBL1-RUVBL2-TRRAP-KAT5)
→
TIP49A/TIP49B complex (RUVBL1-RUVBL2)
(modification, collaborate)
Wood et al., Mol Cell 2000, Frank et al., EMBO Rep 2003
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database C-MYC pathway:
MYC/Max/TRRAP/TIP60/TIP49A/TIP49B/BAF53 complex (MYC-MAX-ACTL6A-RUVBL1-RUVBL2-TRRAP-KAT5)
→
MYC/Max complex (MYC-MAX)
(modification, collaborate)
Wood et al., Mol Cell 2000, Frank et al., EMBO Rep 2003
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database C-MYC pathway:
TIP49A/TIP49B complex (RUVBL1-RUVBL2)
→
MYC/Max complex (MYC-MAX)
(modification, collaborate)
Wood et al., Mol Cell 2000, Frank et al., EMBO Rep 2003
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional repression:
MYC/Max/NF-Y complex (MYC-MAX-NFYA-NFYC-NFYB)
→
PDGFRB (PDGFRB)
(transcription, inhibits)
Izumi et al., J Cell Sci 2001
Evidence: mutant phenotype, reporter gene, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional repression:
MYC/Max/NF-Y complex (MYC-MAX-NFYA-NFYC-NFYB)
→
NF-Y complex (NFYA-NFYB-NFYC)
(transcription, inhibits)
Izumi et al., J Cell Sci 2001
Evidence: mutant phenotype, reporter gene, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional activation:
MYC/Max/TRRAP/TIP60/TIP49A/TIP49B/BAF53 complex (MYC-MAX-ACTL6A-RUVBL1-RUVBL2-TRRAP-KAT5)
→
CAD (CAD)
(transcription, activates)
Eberhardy et al., J Biol Chem 2001, Frank et al., EMBO Rep 2003, Boyd et al., Proc Natl Acad Sci U S A 1998, Bush et al., Genes Dev 1998
Evidence: mutant phenotype, reporter gene, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional repression:
MIZ-1 (ZBTB17)
→
MYC/Max/MIZ-1 complex (MYC-MAX-ZBTB17)
(transcription, activates)
Cappellen et al., EMBO Rep 2007*
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional activation:
MYC/Max/PIM1 complex (MYC-MAX-PIM1)
→
ID2 (ID2)
(transcription, activates)
Zippo et al., Nat Cell Biol 2007
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional repression:
MYC/Max/MIZ-1 complex (MYC-MAX-ZBTB17)
→
beta4 Integrin (ITGB4)
(transcription, inhibits)
Gebhardt et al., J Cell Biol 2006*
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional activation:
MYC/Max/TRRAP/TIP60/TIP49A/TIP49B/BAF53 complex (MYC-MAX-ACTL6A-RUVBL1-RUVBL2-TRRAP-KAT5)
→
NME1 (NME1)
(transcription, activates)
Frank et al., EMBO Rep 2003
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional activation:
MYC/Max/TRRAP/GCN5/STAF65G/SPT3/TAF9/TAF10/TAF12/core Mediator complex (MYC-MAX-SUPT7L-SUPT3H-TAF9-TAF10-TAF12-TRRAP-KAT2A)
→
nucleus (EP300/CREBBP)
(transcription, activates)
Greenberg et al., Oncogene 1999, Faiola et al., Mol Cell Biol 2005, Liu et al., Mol Cell Biol 2008
Evidence: mutant phenotype, assay, reporter gene, physical interaction
-
NCI Pathway Database C-MYC pathway:
MYC/Max/DNA replication preinitiation complex complex (MYC-MAX)
→
MYC/Max complex (MYC-MAX)
(modification, collaborate)
Dominguez-Sola et al., Nature 2007*
Evidence: assay, physical interaction
-
NCI Pathway Database C-MYC pathway:
STAF65G (SUPT7L)
→
MYC/Max complex (MYC-MAX)
(modification, collaborate)
McMahon et al., Mol Cell Biol 2000, Park et al., Genes Dev 2001, Liu et al., J Biol Chem 2003, Liu et al., Mol Cell Biol 2008, McMahon et al., Cell 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database C-MYC pathway:
STAF65G (SUPT7L)
→
MYC/Max/TRRAP/GCN5/STAF65G/SPT3/TAF9/TAF10/TAF12/core Mediator complex (MYC-MAX-SUPT7L-SUPT3H-TAF9-TAF10-TAF12-TRRAP-KAT2A)
(modification, collaborate)
McMahon et al., Mol Cell Biol 2000, Park et al., Genes Dev 2001, Liu et al., J Biol Chem 2003, Liu et al., Mol Cell Biol 2008, McMahon et al., Cell 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database C-MYC pathway:
TAF10 (TAF10)
→
MYC/Max complex (MYC-MAX)
(modification, collaborate)
McMahon et al., Mol Cell Biol 2000, Park et al., Genes Dev 2001, Liu et al., J Biol Chem 2003, Liu et al., Mol Cell Biol 2008, McMahon et al., Cell 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database C-MYC pathway:
TAF10 (TAF10)
→
MYC/Max/TRRAP/GCN5/STAF65G/SPT3/TAF9/TAF10/TAF12/core Mediator complex (MYC-MAX-SUPT7L-SUPT3H-TAF9-TAF10-TAF12-TRRAP-KAT2A)
(modification, collaborate)
McMahon et al., Mol Cell Biol 2000, Park et al., Genes Dev 2001, Liu et al., J Biol Chem 2003, Liu et al., Mol Cell Biol 2008, McMahon et al., Cell 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database C-MYC pathway:
TAF12 (TAF12)
→
MYC/Max complex (MYC-MAX)
(modification, collaborate)
McMahon et al., Mol Cell Biol 2000, Park et al., Genes Dev 2001, Liu et al., J Biol Chem 2003, Liu et al., Mol Cell Biol 2008, McMahon et al., Cell 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database C-MYC pathway:
TAF12 (TAF12)
→
MYC/Max/TRRAP/GCN5/STAF65G/SPT3/TAF9/TAF10/TAF12/core Mediator complex (MYC-MAX-SUPT7L-SUPT3H-TAF9-TAF10-TAF12-TRRAP-KAT2A)
(modification, collaborate)
McMahon et al., Mol Cell Biol 2000, Park et al., Genes Dev 2001, Liu et al., J Biol Chem 2003, Liu et al., Mol Cell Biol 2008, McMahon et al., Cell 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database C-MYC pathway:
SPT3 (SUPT3H)
→
MYC/Max complex (MYC-MAX)
(modification, collaborate)
McMahon et al., Mol Cell Biol 2000, Park et al., Genes Dev 2001, Liu et al., J Biol Chem 2003, Liu et al., Mol Cell Biol 2008, McMahon et al., Cell 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database C-MYC pathway:
SPT3 (SUPT3H)
→
MYC/Max/TRRAP/GCN5/STAF65G/SPT3/TAF9/TAF10/TAF12/core Mediator complex (MYC-MAX-SUPT7L-SUPT3H-TAF9-TAF10-TAF12-TRRAP-KAT2A)
(modification, collaborate)
McMahon et al., Mol Cell Biol 2000, Park et al., Genes Dev 2001, Liu et al., J Biol Chem 2003, Liu et al., Mol Cell Biol 2008, McMahon et al., Cell 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database C-MYC pathway:
MYC/Max complex (MYC-MAX)
→
TAF9 (TAF9)
(modification, collaborate)
McMahon et al., Mol Cell Biol 2000, Park et al., Genes Dev 2001, Liu et al., J Biol Chem 2003, Liu et al., Mol Cell Biol 2008, McMahon et al., Cell 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database C-MYC pathway:
MYC/Max complex (MYC-MAX)
→
MYC/Max/TRRAP/GCN5/STAF65G/SPT3/TAF9/TAF10/TAF12/core Mediator complex (MYC-MAX-SUPT7L-SUPT3H-TAF9-TAF10-TAF12-TRRAP-KAT2A)
(modification, collaborate)
McMahon et al., Mol Cell Biol 2000, Park et al., Genes Dev 2001, Liu et al., J Biol Chem 2003, Liu et al., Mol Cell Biol 2008, McMahon et al., Cell 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database C-MYC pathway:
MYC/Max complex (MYC-MAX)
→
TRRAP/GCN5 complex (TRRAP-KAT2A)
(modification, collaborate)
McMahon et al., Mol Cell Biol 2000, Park et al., Genes Dev 2001, Liu et al., J Biol Chem 2003, Liu et al., Mol Cell Biol 2008, McMahon et al., Cell 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database C-MYC pathway:
TAF9 (TAF9)
→
MYC/Max/TRRAP/GCN5/STAF65G/SPT3/TAF9/TAF10/TAF12/core Mediator complex (MYC-MAX-SUPT7L-SUPT3H-TAF9-TAF10-TAF12-TRRAP-KAT2A)
(modification, collaborate)
McMahon et al., Mol Cell Biol 2000, Park et al., Genes Dev 2001, Liu et al., J Biol Chem 2003, Liu et al., Mol Cell Biol 2008, McMahon et al., Cell 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database C-MYC pathway:
MYC/Max/TRRAP/GCN5/STAF65G/SPT3/TAF9/TAF10/TAF12/core Mediator complex (MYC-MAX-SUPT7L-SUPT3H-TAF9-TAF10-TAF12-TRRAP-KAT2A)
→
TRRAP/GCN5 complex (TRRAP-KAT2A)
(modification, collaborate)
McMahon et al., Mol Cell Biol 2000, Park et al., Genes Dev 2001, Liu et al., J Biol Chem 2003, Liu et al., Mol Cell Biol 2008, McMahon et al., Cell 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database C-MYC pathway:
PML4 (PML)
→
MYC/Max/PML4 complex (MYC-MAX-PML)
(modification, collaborate)
Buschbeck et al., Oncogene 2007*
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database C-MYC pathway:
PML4 (PML)
→
MYC/Max complex (MYC-MAX)
(modification, collaborate)
Buschbeck et al., Oncogene 2007*
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database C-MYC pathway:
MYC/Max/PML4 complex (MYC-MAX-PML)
→
MYC/Max complex (MYC-MAX)
(modification, collaborate)
Buschbeck et al., Oncogene 2007*
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional repression:
MIZ-1 (ZBTB17)
→
MYC/Max/MIZ-1 complex (MYC-MAX-ZBTB17)
(transcription, activates)
Fernandez et al., Genes Dev 2003*, Patel et al., J Biol Chem 2006*, Patel et al., J Biol Chem 2007*
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional repression:
MIZ-1/p300 complex (ZBTB17-EP300)
→
MYC/Max/MIZ-1 complex (MYC-MAX-ZBTB17)
(modification, collaborate)
Staller et al., Nat Cell Biol 2001, Peukert et al., EMBO J 1997, Salghetti et al., EMBO J 1999
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional repression:
MIZ-1/p300 complex (ZBTB17-EP300)
→
MYC/Max complex (MYC-MAX)
(modification, collaborate)
Staller et al., Nat Cell Biol 2001, Peukert et al., EMBO J 1997, Salghetti et al., EMBO J 1999
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional repression:
p300 (EP300)
→
MYC/Max/MIZ-1 complex (MYC-MAX-ZBTB17)
(modification, collaborate)
Staller et al., Nat Cell Biol 2001, Peukert et al., EMBO J 1997, Salghetti et al., EMBO J 1999
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional repression:
p300 (EP300)
→
MYC/Max complex (MYC-MAX)
(modification, collaborate)
Staller et al., Nat Cell Biol 2001, Peukert et al., EMBO J 1997, Salghetti et al., EMBO J 1999
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional repression:
MIZ-1 (ZBTB17)
→
MYC/Max/MIZ-1 complex (MYC-MAX-ZBTB17)
(modification, collaborate)
Staller et al., Nat Cell Biol 2001, Peukert et al., EMBO J 1997, Salghetti et al., EMBO J 1999
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional repression:
MIZ-1 (ZBTB17)
→
MYC/Max complex (MYC-MAX)
(modification, collaborate)
Staller et al., Nat Cell Biol 2001, Peukert et al., EMBO J 1997, Salghetti et al., EMBO J 1999
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional repression:
MYC/Max/MIZ-1 complex (MYC-MAX-ZBTB17)
→
MYC/Max complex (MYC-MAX)
(modification, collaborate)
Staller et al., Nat Cell Biol 2001, Peukert et al., EMBO J 1997, Salghetti et al., EMBO J 1999
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional activation:
HECT9 (HUWE1)
→
MYC/Max complex (MYC-MAX)
(modification, activates)
Adhikary et al., Cell 2005
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional repression:
IRF-8 (IRF8)
→
MYC/Max/MIZ-1 complex (MYC-MAX-ZBTB17)
(modification, collaborate)
Alter-Koltunoff et al., J Biol Chem 2008, Peukert et al., EMBO J 1997, Salghetti et al., EMBO J 1999
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional repression:
IRF-8 (IRF8)
→
MYC/Max complex (MYC-MAX)
(modification, collaborate)
Alter-Koltunoff et al., J Biol Chem 2008, Peukert et al., EMBO J 1997, Salghetti et al., EMBO J 1999
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional repression:
MIZ-1/IRF8 complex (ZBTB17-IRF8)
→
MYC/Max/MIZ-1 complex (MYC-MAX-ZBTB17)
(modification, collaborate)
Alter-Koltunoff et al., J Biol Chem 2008, Peukert et al., EMBO J 1997, Salghetti et al., EMBO J 1999
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional repression:
MIZ-1/IRF8 complex (ZBTB17-IRF8)
→
MYC/Max complex (MYC-MAX)
(modification, collaborate)
Alter-Koltunoff et al., J Biol Chem 2008, Peukert et al., EMBO J 1997, Salghetti et al., EMBO J 1999
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional repression:
MYC/Max/MIZ-1 complex (MYC-MAX-ZBTB17)
→
MIZ-1 (ZBTB17)
(modification, collaborate)
Alter-Koltunoff et al., J Biol Chem 2008, Peukert et al., EMBO J 1997, Salghetti et al., EMBO J 1999
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional repression:
MYC/Max/MIZ-1 complex (MYC-MAX-ZBTB17)
→
MYC/Max complex (MYC-MAX)
(modification, collaborate)
Alter-Koltunoff et al., J Biol Chem 2008, Peukert et al., EMBO J 1997, Salghetti et al., EMBO J 1999
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional repression:
MIZ-1 (ZBTB17)
→
MYC/Max complex (MYC-MAX)
(modification, collaborate)
Alter-Koltunoff et al., J Biol Chem 2008, Peukert et al., EMBO J 1997, Salghetti et al., EMBO J 1999
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional repression:
SMAD2-3/SMAD4/MYC/Max/MIZ-1 complex (MYC-MAX-ZBTB17-SMAD2_SMAD3-SMAD4)
→
SMAD2-3/SMAD4 complex (SMAD2_SMAD3-SMAD4)
(modification, collaborate)
Feng et al., Mol Cell 2002
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional repression:
SMAD2-3/SMAD4/MYC/Max/MIZ-1 complex (MYC-MAX-ZBTB17-SMAD2_SMAD3-SMAD4)
→
MYC/Max/MIZ-1 complex (MYC-MAX-ZBTB17)
(modification, collaborate)
Feng et al., Mol Cell 2002
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional repression:
SMAD2-3/SMAD4 complex (SMAD2_SMAD3-SMAD4)
→
MYC/Max/MIZ-1 complex (MYC-MAX-ZBTB17)
(modification, collaborate)
Feng et al., Mol Cell 2002
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional repression:
MIZ-1 (ZBTB17)
→
MYC/Max/MIZ-1 complex (MYC-MAX-ZBTB17)
(transcription, activates)
Zhang et al., J Biol Chem 2006*
Evidence: mutant phenotype, reporter gene, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional activation:
MYC/Max/TRRAP/TIP60/TIP49A/TIP49B/BAF53 complex (MYC-MAX-ACTL6A-RUVBL1-RUVBL2-TRRAP-KAT5)
→
PTMA (PTMA)
(transcription, activates)
Frank et al., EMBO Rep 2003, Eilers et al., EMBO J 1991, Gaubatz et al., Mol Cell Biol 1994
Evidence: mutant phenotype, reporter gene, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional activation:
SMAD3/SMAD4 complex (SMAD3-SMAD4)
→
MYC/Max complex (MYC-MAX)
(transcription, activates)
Smith et al., Oncogene 2009*
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional activation:
MYC/Max/TRRAP/TIP60/TIP49A/TIP49B/BAF53 complex (MYC-MAX-ACTL6A-RUVBL1-RUVBL2-TRRAP-KAT5)
→
MYC/Max/RPL11 complex (MYC-MAX-RPL11)
(transcription, activates)
Greasley et al., Nucleic Acids Res 2000, Frank et al., EMBO Rep 2003, Adhikary et al., Cell 2005, Dai et al., EMBO J 2007
Evidence: mutant phenotype, reporter gene, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional activation:
MYC/Max/TRRAP/TIP60/TIP49A/TIP49B/BAF53 complex (MYC-MAX-ACTL6A-RUVBL1-RUVBL2-TRRAP-KAT5)
→
nucleus (EP300/CREBBP)
(transcription, activates)
Greasley et al., Nucleic Acids Res 2000, Frank et al., EMBO Rep 2003, Adhikary et al., Cell 2005, Dai et al., EMBO J 2007
Evidence: mutant phenotype, reporter gene, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional activation:
MYC/Max/TRRAP/TIP60/TIP49A/TIP49B/BAF53 complex (MYC-MAX-ACTL6A-RUVBL1-RUVBL2-TRRAP-KAT5)
→
Nucleolin (NCL)
(transcription, activates)
Greasley et al., Nucleic Acids Res 2000, Frank et al., EMBO Rep 2003, Adhikary et al., Cell 2005, Dai et al., EMBO J 2007
Evidence: mutant phenotype, reporter gene, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional activation:
MYC/Max/RPL11 complex (MYC-MAX-RPL11)
→
nucleus (EP300/CREBBP)
(transcription, inhibits)
Greasley et al., Nucleic Acids Res 2000, Frank et al., EMBO Rep 2003, Adhikary et al., Cell 2005, Dai et al., EMBO J 2007
Evidence: mutant phenotype, reporter gene, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional activation:
MYC/Max/RPL11 complex (MYC-MAX-RPL11)
→
Nucleolin (NCL)
(transcription, inhibits)
Greasley et al., Nucleic Acids Res 2000, Frank et al., EMBO Rep 2003, Adhikary et al., Cell 2005, Dai et al., EMBO J 2007
Evidence: mutant phenotype, reporter gene, physical interaction
-
NCI Pathway Database C-MYC pathway:
Fbw7-gamma (FBXW7)
→
MYC/Max complex (MYC-MAX)
(modification, activates)
Yada et al., EMBO J 2004, Welcker et al., Proc Natl Acad Sci U S A 2004*
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional repression:
MYC/Max/HDAC3 complex (MYC-MAX-HDAC3)
→
MYC/Max/MIZ-1 complex (MYC-MAX-ZBTB17)
(transcription, inhibits)
Barsyte-Lovejoy et al., Oncogene 2004, Kurland et al., Cancer Res 2008
Evidence: mutant phenotype, reporter gene, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional repression:
MYC/Max/HDAC3 complex (MYC-MAX-HDAC3)
→
CHOP (DDIT3)
(transcription, inhibits)
Barsyte-Lovejoy et al., Oncogene 2004, Kurland et al., Cancer Res 2008
Evidence: mutant phenotype, reporter gene, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional repression:
MYC/Max/MIZ-1 complex (MYC-MAX-ZBTB17)
→
CHOP (DDIT3)
(transcription, inhibits)
Barsyte-Lovejoy et al., Oncogene 2004, Kurland et al., Cancer Res 2008
Evidence: mutant phenotype, reporter gene, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional repression:
DNMT3A (DNMT3A)
→
MYC/Max/MIZ-1 complex (MYC-MAX-ZBTB17)
(modification, collaborate)
Brenner et al., EMBO J 2005, Liu et al., Oncogene 2010
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional repression:
DNMT3A (DNMT3A)
→
MYC/Max/MIZ-1/DNMT3A/GFI1 complex (MYC-MAX-ZBTB17-DNMT3A-GFI1)
(modification, collaborate)
Brenner et al., EMBO J 2005, Liu et al., Oncogene 2010
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional repression:
GFI1 (GFI1)
→
MYC/Max/MIZ-1 complex (MYC-MAX-ZBTB17)
(modification, collaborate)
Brenner et al., EMBO J 2005, Liu et al., Oncogene 2010
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional repression:
GFI1 (GFI1)
→
MYC/Max/MIZ-1/DNMT3A/GFI1 complex (MYC-MAX-ZBTB17-DNMT3A-GFI1)
(modification, collaborate)
Brenner et al., EMBO J 2005, Liu et al., Oncogene 2010
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional repression:
MYC/Max/MIZ-1 complex (MYC-MAX-ZBTB17)
→
MYC/Max/MIZ-1/DNMT3A/GFI1 complex (MYC-MAX-ZBTB17-DNMT3A-GFI1)
(modification, collaborate)
Brenner et al., EMBO J 2005, Liu et al., Oncogene 2010
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database C-MYC pathway:
MYC/Max/MIZ-1 complex (MYC-MAX-ZBTB17)
→
MIZ-1 (ZBTB17)
(modification, collaborate)
Peukert et al., EMBO J 1997, Salghetti et al., EMBO J 1999
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database C-MYC pathway:
MYC/Max/MIZ-1 complex (MYC-MAX-ZBTB17)
→
MYC/Max complex (MYC-MAX)
(modification, collaborate)
Peukert et al., EMBO J 1997, Salghetti et al., EMBO J 1999
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database C-MYC pathway:
MIZ-1 (ZBTB17)
→
MYC/Max complex (MYC-MAX)
(modification, collaborate)
Peukert et al., EMBO J 1997, Salghetti et al., EMBO J 1999
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional activation:
MYC/Max/TRRAP/GCN5/STAF65G/SPT3/TAF9/TAF10/TAF12/core Mediator complex (MYC-MAX-SUPT7L-SUPT3H-TAF9-TAF10-TAF12-TRRAP-KAT2A)
→
nucleus (EP300/CREBBP)
(transcription, activates)
Bouchard et al., EMBO J 1999, Bouchard et al., Genes Dev 2001, Vervoorts et al., EMBO Rep 2003
Evidence: mutant phenotype, assay, reporter gene, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional repression:
BRCA1 (BRCA1)
→
MYC/Max complex (MYC-MAX)
(transcription, inhibits)
Kennedy et al., Cancer Res 2005*
Evidence: mutant phenotype, reporter gene, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional repression:
TBP (TBP)
→
MYC/Max complex (MYC-MAX)
(transcription, activates)
Kennedy et al., Cancer Res 2005*
Evidence: mutant phenotype, reporter gene, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional activation:
MYC/Max/TRRAP/TIP60/TIP49A/TIP49B/BAF53 complex (MYC-MAX-ACTL6A-RUVBL1-RUVBL2-TRRAP-KAT5)
→
GPAT (GPAM)
(transcription, activates)
Frank et al., EMBO Rep 2003
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database C-MYC pathway:
SKP2 (SKP2)
→
MYC/Max complex (MYC-MAX)
(modification, activates)
Kim et al., Mol Cell 2003*, von der Lehr et al., Mol Cell 2003*
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional activation:
MYC/Max/RPL11 complex (MYC-MAX-RPL11)
→
RPL11 (RPL11)
(modification, collaborate)
Dai et al., EMBO J 2007
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional activation:
MYC/Max/RPL11 complex (MYC-MAX-RPL11)
→
MYC/Max complex (MYC-MAX)
(modification, collaborate)
Dai et al., EMBO J 2007
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional activation:
RPL11 (RPL11)
→
MYC/Max complex (MYC-MAX)
(modification, collaborate)
Dai et al., EMBO J 2007
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional activation:
MYC/Max/Cbp/p300 complex (MYC-MAX-EP300_CREBBP)
→
ODC (ODC1)
(transcription, activates)
Vervoorts et al., EMBO Rep 2003, Wagner et al., Cell Growth Differ 1993*, Bello-Fernandez et al., Proc Natl Acad Sci U S A 1993*
Evidence: mutant phenotype, assay, reporter gene, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional activation:
MYC/Max/TRRAP/GCN5/STAF65G/SPT3/TAF9/TAF10/TAF12/core Mediator complex (MYC-MAX-SUPT7L-SUPT3H-TAF9-TAF10-TAF12-TRRAP-KAT2A)
→
HSP60 (HSPD1)
(transcription, activates)
Frank et al., Genes Dev 2001, Liu et al., Mol Cell Biol 2008
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database C-MYC pathway:
HBP1 (HBP1)
→
MYC/Max/HBP1 complex (MYC-MAX-HBP1)
(modification, collaborate)
Escamilla-Powers et al., J Biol Chem 2010*
Evidence: physical interaction
-
NCI Pathway Database C-MYC pathway:
HBP1 (HBP1)
→
MYC/Max complex (MYC-MAX)
(modification, collaborate)
Escamilla-Powers et al., J Biol Chem 2010*
Evidence: physical interaction
-
NCI Pathway Database C-MYC pathway:
MYC/Max/HBP1 complex (MYC-MAX-HBP1)
→
MYC/Max complex (MYC-MAX)
(modification, collaborate)
Escamilla-Powers et al., J Biol Chem 2010*
Evidence: physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional repression:
p107 (RBL1)
→
MYC/Max complex (MYC-MAX)
(transcription, inhibits)
Luo et al., Oncogene 2004*, Penn et al., EMBO J 1990*, Facchini et al., Mol Cell Biol 1997*
Evidence: mutant phenotype, reporter gene, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional activation:
MYC/Max/TRRAP/TIP60/TIP49A/TIP49B/BAF53 complex (MYC-MAX-ACTL6A-RUVBL1-RUVBL2-TRRAP-KAT5)
→
HSP60 (HSPD1)
(transcription, activates)
Frank et al., Genes Dev 2001, Frank et al., EMBO Rep 2003
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional repression:
SMAD2-3/SMAD4/MYC/Max/MIZ-1 complex (MYC-MAX-ZBTB17-SMAD2_SMAD3-SMAD4)
→
SMAD2-3/SMAD4/SP1 complex (SMAD2_SMAD3-SMAD4-SP1)
(transcription, inhibits)
Staller et al., Nat Cell Biol 2001, Seoane et al., Nat Cell Biol 2001, Feng et al., Mol Cell 2002
Evidence: mutant phenotype, reporter gene, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional repression:
SP1 (SP1)
→
MYC/Max/MIZ-1 complex (MYC-MAX-ZBTB17)
(transcription, activates)
Camarero et al., Mol Cancer Res 2006*
Evidence: mutant phenotype, reporter gene, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional repression:
MIZ-1 (ZBTB17)
→
MYC/Max/MIZ-1 complex (MYC-MAX-ZBTB17)
(transcription, activates)
Camarero et al., Mol Cancer Res 2006*
Evidence: mutant phenotype, reporter gene, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional repression:
MIZ-1 (ZBTB17)
→
MYC/Max/MIZ-1 complex (MYC-MAX-ZBTB17)
(cell cycle arrest, activates)
Peukert et al., EMBO J 1997
Evidence: mutant phenotype, assay
-
NCI Pathway Database Validated targets of C-MYC transcriptional activation:
UBF (UBTF)
→
MYC/Max complex (MYC-MAX)
(rRNA transcription, activates)
Poortinga et al., EMBO J 2004*, Arabi et al., Nat Cell Biol 2005*, Grandori et al., Nat Cell Biol 2005*
Evidence: mutant phenotype, assay
-
NCI Pathway Database Validated targets of C-MYC transcriptional activation:
TRRAP (TRRAP)
→
MYC/Max complex (MYC-MAX)
(rRNA transcription, activates)
Poortinga et al., EMBO J 2004*, Arabi et al., Nat Cell Biol 2005*, Grandori et al., Nat Cell Biol 2005*
Evidence: mutant phenotype, assay
-
NCI Pathway Database C-MYC pathway:
p14ARF (CDKN2A)
→
MYC/Max/p14ARF complex (MYC-MAX-CDKN2A)
(modification, collaborate)
Datta et al., J Biol Chem 2004*, Qi et al., Nature 2004*
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database C-MYC pathway:
p14ARF (CDKN2A)
→
MYC/Max complex (MYC-MAX)
(modification, collaborate)
Datta et al., J Biol Chem 2004*, Qi et al., Nature 2004*
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database C-MYC pathway:
MYC/Max/p14ARF complex (MYC-MAX-CDKN2A)
→
MYC/Max complex (MYC-MAX)
(modification, collaborate)
Datta et al., J Biol Chem 2004*, Qi et al., Nature 2004*
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional repression:
FOXO3A (FOXO3)
→
MYC/Max complex (MYC-MAX)
(transcription, activates)
Yang et al., Oncogene 2001*, Chandramohan et al., J Cell Biochem 2008*
Evidence: mutant phenotype, reporter gene, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional repression:
MIZ-1 (ZBTB17)
→
MYC/Max/MIZ-1 complex (MYC-MAX-ZBTB17)
(transcription, activates)
Kime et al., Biochem J 2003*, Marcotte et al., J Cell Biochem 2005*
Evidence: reporter gene, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional activation:
MYC/Max/Cbp/p300 complex (MYC-MAX-EP300_CREBBP)
→
nucleus (EP300/CREBBP)
(modification, collaborate)
Vervoorts et al., EMBO Rep 2003, Adhikary et al., Cell 2005
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional activation:
MYC/Max/Cbp/p300 complex (MYC-MAX-EP300_CREBBP)
→
MYC/Max complex (MYC-MAX)
(modification, collaborate)
Vervoorts et al., EMBO Rep 2003, Adhikary et al., Cell 2005
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional activation:
nucleus (EP300/CREBBP)
→
MYC/Max complex (MYC-MAX)
(modification, collaborate)
Vervoorts et al., EMBO Rep 2003, Adhikary et al., Cell 2005
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional activation:
MYC/Max/Cbp/p300 complex (MYC-MAX-EP300_CREBBP)
→
eIF2A (EIF2S1)
(transcription, activates)
Vervoorts et al., EMBO Rep 2003, Rosenwald et al., Proc Natl Acad Sci U S A 1993*
Evidence: assay, physical interaction
-
NCI Pathway Database C-MYC pathway:
PAK2 (PAK2)
→
MYC/Max complex (MYC-MAX)
(modification, activates)
Huang et al., Mol Cell Biol 2004*
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database C-MYC pathway:
Max (MAX)
→
MYC (MYC)
(modification, collaborate)
Huang et al., Mol Cell Biol 2004*
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database C-MYC pathway:
Max (MAX)
→
MYC/Max complex (MYC-MAX)
(modification, collaborate)
Huang et al., Mol Cell Biol 2004*
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database C-MYC pathway:
MYC (MYC)
→
MYC/Max complex (MYC-MAX)
(modification, collaborate)
Huang et al., Mol Cell Biol 2004*
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database C-MYC pathway:
Axin1/GSK3beta/PIN1/PP2A-B56alpha complex (AXIN1-GSK3B-PIN1-PPP2CA-PPP2R5A)
→
MYC/Max complex (MYC-MAX)
(modification, activates)
Sears et al., Genes Dev 2000, Gregory et al., J Biol Chem 2003, Yeh et al., Nat Cell Biol 2004, Arnold et al., Mol Cell Biol 2006, Arnold et al., EMBO J 2009
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional repression:
TBP (TBP)
→
MYC/Max/MIZ-1 complex (MYC-MAX-ZBTB17)
(transcription, activates)
Zhang et al., J Cell Biochem 2007
Evidence: physical interaction, other species
-
NCI Pathway Database Validated targets of C-MYC transcriptional repression:
CREB1 (CREB1)
→
MYC/Max/MIZ-1 complex (MYC-MAX-ZBTB17)
(transcription, activates)
Zhang et al., J Cell Biochem 2007
Evidence: physical interaction, other species
-
NCI Pathway Database Validated targets of C-MYC transcriptional repression:
SP1 (SP1)
→
MYC/Max/MIZ-1 complex (MYC-MAX-ZBTB17)
(transcription, activates)
Zhang et al., J Cell Biochem 2007
Evidence: physical interaction, other species
-
Reactome Reaction:
MYC
→
MAX
(direct_complex)
-
WikiPathways Pathways Affected in Adenoid Cystic Carcinoma:
MYC/MYCN
→
MAX
(activation)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind Interaction:
MYC
—
MAX
Naderi et al., J Cell Physiol 1999*
-
IRef Bind Interaction:
MYC
—
MAX
Mac Partlin et al., Oncogene 2003*
-
IRef Bind_translation Interaction:
MAX
—
MYC
(unspecified method)
Naderi et al., J Cell Physiol 1999*
-
IRef Bind_translation Interaction:
MAX
—
MYC
(affinity chromatography technology)
Mac Partlin et al., Oncogene 2003*
-
IRef Biogrid Interaction:
MYC
—
MAX
(direct interaction, pull down)
Okano et al., Genes Dev 1999*
-
IRef Biogrid Interaction:
MYC
—
MAX
(colocalization, biochemical)
Agrawal et al., Cell cycle (Georgetown, Tex.) 2010
-
IRef Biogrid Interaction:
MYC
—
MAX
(physical association, affinity chromatography technology)
Agrawal et al., Cell cycle (Georgetown, Tex.) 2010
-
IRef Biogrid Interaction:
MYC
—
MAX
(physical association, affinity chromatography technology)
Wong et al., Mol Cell Biol 2013*
-
IRef Biogrid Interaction:
MYC
—
MAX
(direct interaction, two hybrid)
Wang et al., Molecular systems biology 2011
-
IRef Biogrid Interaction:
MYC
—
MAX
(physical association, affinity chromatography technology)
Yu et al., Int J Cancer 2009*
-
IRef Biogrid Interaction:
MYC
—
MAX
(physical association, affinity chromatography technology)
Ewing et al., Molecular systems biology 2007
-
IRef Biogrid Interaction:
MYC
—
MAX
(physical association, affinity chromatography technology)
McMahon et al., Mol Cell Biol 2000
-
IRef Biogrid Interaction:
MYC
—
MAX
(physical association, affinity chromatography technology)
McMahon et al., Cell 1998
-
IRef Biogrid Interaction:
MYC
—
MAX
(direct interaction, two hybrid)
Cheng et al., Nat Genet 1999*
-
IRef Biogrid Interaction:
MYC
—
MAX
(direct interaction, two hybrid)
Mac Partlin et al., Oncogene 2003*
-
IRef Biogrid Interaction:
MYC
—
MAX
(direct interaction, pull down)
Mac Partlin et al., Oncogene 2003*
-
IRef Biogrid Interaction:
MYC
—
MAX
(direct interaction, pull down)
Blackwood et al., Science 1991*
-
IRef Biogrid Interaction:
MYC
—
MAX
(direct interaction, pull down)
Lee et al., Proc Natl Acad Sci U S A 2002*
-
IRef Biogrid Interaction:
MYC
—
MAX
(direct interaction, two hybrid)
Billin et al., J Biol Chem 1999*
-
IRef Biogrid Interaction:
MYC
—
MAX
(direct interaction, two hybrid)
Gupta et al., Oncogene 1998*
-
IRef Biogrid Interaction:
MYC
—
MAX
(direct interaction, two hybrid)
Meroni et al., EMBO J 1997*
-
IRef Biogrid Interaction:
MYC
—
MAX
(direct interaction, pull down)
Nair et al., Cell 2003*
-
IRef Biogrid Interaction:
MYC
—
MAX
(association, x-ray crystallography)
Nair et al., Cell 2003*
-
IRef Biogrid Interaction:
MYC
—
MAX
(direct interaction, pull down)
FitzGerald et al., Oncogene 1999*
-
IRef Biogrid Interaction:
MYC
—
MAX
(direct interaction, two hybrid)
Meroni et al., Oncogene 2000*
-
IRef Biogrid Interaction:
MYC
—
MAX
(physical association, affinity chromatography technology)
Hatakeyama et al., Cancer Res 2005*
-
IRef Biogrid Interaction:
MYC
—
MAX
(direct interaction, two hybrid)
Bandyopadhyay et al., Nat Methods 2010
-
IRef Biogrid Interaction:
MYC
—
MAX
(physical association, affinity chromatography technology)
Matsuoka et al., Oncol Rep 2009*
-
IRef Biogrid Interaction:
MYC
—
MAX
(physical association, affinity chromatography technology)
Cowling et al., Mol Cell Biol 2006*
-
IRef Biogrid Interaction:
MYC
—
MAX
(physical association, affinity chromatography technology)
Wang et al., J Cell Physiol 2006*
-
IRef Biogrid Interaction:
MYC
—
MAX
(physical association, affinity chromatography technology)
Faiola et al., Mol Cell Biol 2005
-
IRef Biogrid Interaction:
MYC
—
MAX
(physical association, affinity chromatography technology)
Siegel et al., J Biol Chem 2003*
-
IRef Biogrid Interaction:
MYC
—
MAX
(physical association, affinity chromatography technology)
Veldman et al., Proc Natl Acad Sci U S A 2003*
-
IRef Biogrid Interaction:
MYC
—
MAX
(physical association, affinity chromatography technology)
Patel et al., Mol Cell Biol 2004*
-
IRef Biogrid Interaction:
MYC
—
MAX
(physical association, affinity chromatography technology)
Patel et al., J Biol Chem 2006*
-
IRef Biogrid Interaction:
MYC
—
MAX
(physical association, affinity chromatography technology)
Liu et al., Proc Natl Acad Sci U S A 2007*
-
IRef Biogrid Interaction:
MYC
—
MAX
(physical association, affinity chromatography technology)
Zhang et al., J Cell Biochem 2007
-
IRef Biogrid Interaction:
MYC
—
MAX
(physical association, affinity chromatography technology)
Gordan et al., Cancer Cell 2007
-
IRef Biogrid Interaction:
MYC
—
MAX
(physical association, affinity chromatography technology)
Gargano et al., Cell cycle (Georgetown, Tex.) 2007*
-
IRef Biogrid Interaction:
MYC
—
MAX
(physical association, affinity chromatography technology)
Zippo et al., Nat Cell Biol 2007
-
IRef Biogrid Interaction:
MYC
—
MAX
(physical association, affinity chromatography technology)
Zhang et al., Mol Endocrinol 2010*
-
IRef Biogrid Interaction:
MYC
—
MAX
(physical association, affinity chromatography technology)
Kim et al., Cell 2010
-
IRef Biogrid Interaction:
MYC
—
MAX
(physical association, affinity chromatography technology)
Koch et al., Cell cycle (Georgetown, Tex.) 2007
-
IRef Biogrid Interaction:
MYC
—
MAX
(direct interaction, fluorescent resonance energy transfer)
Koch et al., Cell cycle (Georgetown, Tex.) 2007
-
IRef Biogrid Interaction:
MYC
—
MAX
(association, x-ray crystallography)
Lavigne et al., J Mol Biol 1998*
-
IRef Biogrid Interaction:
MYC
—
MAX
(physical association, affinity chromatography technology)
Amente et al., FEBS Lett 2007*
-
IRef Biogrid Interaction:
MYC
—
MAX
(physical association, affinity chromatography technology)
Ayer et al., Genes Dev 1993*
-
IRef Biogrid Interaction:
MYC
—
MAX
(physical association, affinity chromatography technology)
Huang et al., Mol Cell Biol 2004*
-
IRef Biogrid Interaction:
MYC
—
MAX
(direct interaction, two hybrid)
Huang et al., Mol Cell Biol 2004*
-
MIPS CORUM MYC-MAX-BLOC1S1 complex:
MYC-MAX-BLOC1S1 complex complex (BLOC1S1-MAX-MYC)
McMahon et al., Mol Cell Biol 2000
-
MIPS CORUM MYC-MAX complex:
MYC-MAX complex complex (MAX-MYC)
Mac Partlin et al., Oncogene 2003*
-
MIPS CORUM MYC-MAX complex:
MYC-MAX complex complex (MAX-MYC)
Ayer et al., Genes Dev 1993*
-
IRef Corum Interaction:
MYC
—
MAX
(association, coimmunoprecipitation)
Mac Partlin et al., Oncogene 2003*
-
IRef Corum Interaction:
MYC
—
MAX
(association, anti bait coimmunoprecipitation)
Ayer et al., Genes Dev 1993*
-
IRef Corum Interaction:
Complex of MYC-MAX-BLOC1S1
(association, coimmunoprecipitation)
McMahon et al., Mol Cell Biol 2000
-
IRef Dip Interaction:
MYC
—
MAX
(physical association, coimmunoprecipitation)
Liu et al., J Biol Chem 2003
-
IRef Dip Interaction:
MYC
—
MAX
(physical association, coimmunoprecipitation)
McMahon et al., Cell 1998
-
IRef Dip Interaction:
MYC
—
MAX
(physical association, affinity chromatography technology)
Shrivastava et al., Science 1993*
-
IRef Hprd Interaction:
MAX
—
MYC
(in vivo)
FitzGerald et al., Oncogene 1999*, Söderberg et al., Nat Methods 2006*, Fujii et al., Mol Cell 2006*, Gordan et al., Cancer Cell 2007, Blackwood et al., Science 1991*, Lavigne et al., J Mol Biol 1998*
-
IRef Hprd Interaction:
MAX
—
MYC
(in vitro)
FitzGerald et al., Oncogene 1999*, Söderberg et al., Nat Methods 2006*, Fujii et al., Mol Cell 2006*, Gordan et al., Cancer Cell 2007, Blackwood et al., Science 1991*, Lavigne et al., J Mol Biol 1998*
-
IRef Hprd Interaction:
Complex of MAX-MYC-BLOC1S1-MYC-MAX-BLOC1S1-MAX-BLOC1S1-MYC
(in vivo)
McMahon et al., Mol Cell Biol 2000
-
IRef Intact Interaction:
MYC
—
MAX
(physical association, anti bait coimmunoprecipitation)
Veldman et al., Proc Natl Acad Sci U S A 2003*
-
IRef Intact Interaction:
MYC
—
MAX
(physical association, anti bait coimmunoprecipitation)
Patel et al., J Biol Chem 2006*
-
IRef Intact Interaction:
MYC
—
MAX
(physical association, anti bait coimmunoprecipitation)
Fujii et al., Mol Cell 2006*
-
IRef Intact Interaction:
MYC
—
MAX
(physical association, anti bait coimmunoprecipitation)
Ewing et al., Molecular systems biology 2007
-
IRef Intact Interaction:
MYC
—
MAX
(physical association, anti bait coimmunoprecipitation)
Gordan et al., Cancer Cell 2007
-
IRef Intact Interaction:
MYC
—
MAX
(physical association, anti bait coimmunoprecipitation)
Conacci-Sorrell et al., Cell 2010*
-
IRef Intact Interaction:
MYC
—
MAX
(physical association, anti tag coimmunoprecipitation)
Conacci-Sorrell et al., Cell 2010*
-
IRef Intact Interaction:
MYC
—
MAX
(physical association, two hybrid pooling approach)
Bandyopadhyay et al., Nat Methods 2010
-
IRef Intact Interaction:
MYC
—
MAX
(physical association, anti tag coimmunoprecipitation)
Mao et al., Int J Biochem Cell Biol 2011*
-
IRef Intact Interaction:
MYC
—
MAX
(physical association, anti bait coimmunoprecipitation)
Mao et al., Int J Biochem Cell Biol 2011*
-
IRef Intact Interaction:
MYC
—
MAX
(physical association, two hybrid)
Wang et al., Molecular systems biology 2011
-
IRef Intact Interaction:
MYC
—
MAX
(direct interaction, nuclear magnetic resonance)
Lavigne et al., J Mol Biol 1998*
-
IRef Intact Interaction:
Complex of 50 proteins
(association, tandem affinity purification)
Agrawal et al., Cell cycle (Georgetown, Tex.) 2010
-
IRef Intact Interaction:
Complex of 88 proteins
(association, tandem affinity purification)
Agrawal et al., Cell cycle (Georgetown, Tex.) 2010
-
IRef Intact Interaction:
Complex of 222 proteins
(association, tandem affinity purification)
Koch et al., Cell cycle (Georgetown, Tex.) 2007
-
IRef Intact Interaction:
Complex of 13 proteins
(association, tandem affinity purification)
Koch et al., Cell cycle (Georgetown, Tex.) 2007
-
IRef Intact Interaction:
Complex of SP1-MYC-PIAS2-MYC-PIAS2-SP1-MAX-MAX
(association, anti bait coimmunoprecipitation)
Gordan et al., Cancer Cell 2007
-
IRef Intact Interaction:
Complex of 13 proteins
(physical association, cosedimentation through density gradient)
Koch et al., Cell cycle (Georgetown, Tex.) 2007
-
IRef Ophid Interaction:
MYC
—
MAX
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
-
IRef Ophid Interaction:
MYC
—
MAX
(aggregation, confirmational text mining)
Lavigne et al., J Mol Biol 1998*
Text-mined interactions from Literome
Kirch et al., Oncogene 1999
:
Expression of human
p53 requires synergistic activation of transcription from the p53 promoter by AP-1, NF-kappaB and
Myc/Max
Harris et al., J Biol Chem 2002
(Neuroblastoma) :
Using transient transfection assays, we show that the
Pax-3 promoter is
activated by both
N-Myc-Max and c-Myc-Max
Chung et al., Cancer Lett 2002
(Stomach Neoplasms) :
Unsaturated fatty acids bind Myc-Max
transcription factor and
inhibit Myc-Max-DNA complex formation
Wiener et al., Exp Cell Res 2004
(Carcinoma, Non-Small-Cell Lung...) :
Our results revealed that inhibition of
c-Myc/Max did not substantially
reduce basal levels of
Fas ligand promoter activity, nor did overexpression of c-Myc significantly induce promoter activity ... Our results revealed that inhibition of
c-Myc/Max did not substantially reduce basal levels of Fas ligand promoter activity, nor did overexpression of
c-Myc significantly
induce promoter activity
Wang et al., J Cell Physiol 2006
(Carcinoma, Hepatocellular...) :
Since the participation of c-Myc protein in transcription requires its dimerization with Max protein, we examined the Myc-Max association in Cpd 5-treated cells and found that
Cpd 5
suppressed Myc-Max dimerization
Zhao et al., Am J Hum Genet 2007
(Genetic Predisposition to Disease) :
Third, we found that an allele of SNP4 ( rs4950928 ), the tagging SNP of CCC, impaired the
MYC/MAX regulated transcriptional activation of
CHI3L1 by altering the transcriptional-factor consensus sequences, and this may be responsible for the decreased expression of the CCC haplotype
Berberich et al., Genes Dev 1992
:
Casein kinase II inhibits the DNA binding activity of Max homodimers but not
Myc/Max heterodimers ... In contrast, phosphorylation of Max and/or
Myc by CKII
had no inhibitory or stimulatory effect on the DNA binding activity of
Myc/Max heterodimers
Boult et al., Br J Cancer 2008
(Adenocarcinoma...) :
Overexpression of c-MYC and
MAD proteins in SEG1 cells
resulted in differential expression of
MYC/MAX/MAD network members and reciprocal changes in proliferation ... Overexpression of
c-MYC and MAD proteins in SEG1 cells
resulted in differential expression of
MYC/MAX/MAD network members and reciprocal changes in proliferation
Yang et al., Hepatology 2009
(Cholestasis...) :
Switch from Mnt-Max to
Myc-Max induces
p53 and cyclin D1 expression and apoptosis during cholestasis in mouse and human hepatocytes ... Switch from Mnt-Max to
Myc-Max induces p53 and
cyclin D1 expression and apoptosis during cholestasis in mouse and human hepatocytes ...
Mnt-Max also binds the E-box sequence but serves as a repressor and
inhibits the enhancer activity of
Myc-Max ... The current work tested the hypothesis that the switch from Mnt-Max to
Myc-Max is
responsible for
p53 and cyclin D1 up-regulation and apoptosis during cholestasis ... The current work tested the hypothesis that the switch from Mnt-Max to
Myc-Max is
responsible for p53 and
cyclin D1 up-regulation and apoptosis during cholestasis
Chappell et al., Genes Dev 2013
:
In this study, we define a mechanism for this by showing that
MYC/MAX complexes
suppress ERK activity by transcriptionally regulating two members of the dual-specificity phosphatase ( DUSP ) family
Gaubatz et al., EMBO J 1995
:
The second mechanism involves a specific interaction between C-terminal domains of AP-2 and the BR/HLH/LZ domain of Myc, but not Max or Mad. Binding of AP-2 to Myc does not preclude association of Myc with Max, but impairs DNA binding of the
Myc/Max complex and
inhibits transactivation by
Myc even in the absence of an overlapping AP-2 binding site
Boyd et al., Mol Cell Biol 1997
:
To determine whether binding of
Myc-Max or USF is
critical for
cad growth regulation, we analyzed promoter constructs which contain mutations in the nucleotides flanking the E box ... This result supports the conclusion that binding of
Myc-Max , but not USF, is
essential for
cad regulation
Schneider et al., Curr Top Microbiol Immunol 1997
(Cell Transformation, Neoplastic) :
Myc transformed cells are also characterised by the loss of expression of a number of genes and this repressive effect of
Myc on gene expression may not be
mediated by the
Myc/Max complex
Facchini et al., FASEB J 1998
(Cell Transformation, Neoplastic) :
Finally, we explore whether direct transactivation of cellular genes by
Myc-Max heterodimers is
sufficient for the growth promoting and transforming activities of
Myc or whether other molecular activities of Myc, such as Myc mediated repression, may play a key role
Zaffran et al., Development 1998
:
pit encodes a DEAD-box RNA helicase, a family of proteins involved in the control of RNA structure in many cellular processes and its closest homologue is a human DEAD-box RNA helicase,
MrDb , whose corresponding gene transcription is directly
activated by
Myc-Max heterodimers ( Grandori, C., Mac, J., Siëbelt, F., Ayer, D. E. and Eisenman, R. N. ( 1996 ) EMBO J. 15, 4344-4357 )
Qin et al., Blood 1999
(Lymphoma, T-Cell, Cutaneous...) :
Interleukin-7 (IL-7) and
IL-15 , which have been identified as growth factors for CTCL cells,
stimulated the DNA binding of JunD and two novel c-Myc recognition site ( E-box ) binding proteins, but not the DNA binding of
c-Myc/Max heterodimers ...
Interleukin-7 (IL-7) and IL-15, which have been identified as growth factors for CTCL cells,
stimulated the DNA binding of JunD and two novel c-Myc recognition site ( E-box ) binding proteins, but not the DNA binding of
c-Myc/Max heterodimers