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NOTCH1 — RRAS
Text-mined interactions from Literome
Hodkinson et al., J Biol Chem 2007
:
Membrane bound
Notch mutants that are inefficiently cleaved or intracellular Notch mutants lacking the ankyrin repeat sequence do not
activate R-Ras or integrins
Karsan et al., Science signaling 2008
(Cardiovascular Diseases...) :
It is proposed that
Notch dependent activation of
R-Ras reverses H-Ras mediated suppression of integrin affinity ...
Activation of
R-Ras by
Notch may be triggered by a noncanonical CSL ( CBF1 or RBP-Jkappa in vertebrates, Suppressor of Hairless in Drosophila, Lag-1 in Caenorhabditis elegans ) -independent pathway