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SDC2 — TAT

Text-mined interactions from Literome

Bugatti et al., Antimicrob Agents Chemother 2007 : Surface plasmon resonance revealed that SSAPs inhibit with a competitive mechanism of action the binding of Tat and gp120 to surface immobilized heparin, an experimental condition that resembles binding to cellular HSPGs. Accordingly, SSAPs inhibited HSPG dependent cell internalization and the transactivating activity of Tat
Bugatti et al., Antiviral Res 2010 : Tat possesses a basic amino acid sequence implicated in heparan sulfate proteoglycan (HSPG) mediated internalization, nuclear localization and transactivation by Tat and in the interaction of Tat with integrins and with the vascular endothelial growth factor receptor 2 ( KDR ) ( kinase insert domain receptor ) ... Accordingly, BSA-Tat-NLS binds to HSPGs of HL3T1 cell surface and inhibits HSPG dependent Tat internalization