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SCAI — SRF

Pathways - manually collected, often from reviews:

• NCI Pathway Database RhoA signaling pathway: SRF(dimer) complex (SRF) → SCAI (SCAI) (modification, collaborate) Brandt et al., Nat Cell Biol 2009*
  Evidence: physical interaction
• NCI Pathway Database RhoA signaling pathway: SRF(dimer) complex (SRF) → SRF(dimer)/MAL(dimer)/SCAI complex (SRF-MKL1-SCAI) (modification, collaborate)
  Brandt et al., Nat Cell Biol 2009*
  Evidence: physical interaction
• NCI Pathway Database RhoA signaling pathway: SCAI (SCAI) → SRF(dimer)/MAL(dimer)/SCAI complex (SRF-MKL1-SCAI) (modification, collaborate)
  Brandt et al., Nat Cell Biol 2009*
  Evidence: physical interaction
• NCI Pathway Database RhoA signaling pathway: SRF(dimer)/MAL(dimer)/SCAI complex (SRF-MKL1-SCAI) → MAL(dimer) complex (MKL1) (modification, collaborate) Brandt et al., Nat Cell Biol 2009*
  Evidence: physical interaction

Text-mined interactions from Literome

Juliano et al., Nat Cell Biol 2009 (Neoplasm Invasiveness) : SCAI inhibits the MAL/SRF transcriptional activator complex that is downstream of Rho GTPase and actin, resulting in reduced expression of beta1-integrins and loss of invasive potential
Ishikawa et al., J Biol Chem 2010 : Furthermore, overexpression of SCAI blocked activin induced SRF transcriptional responses and dendritic complexity