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GDF2 — SLPI

Text-mined interactions from Literome

Sumita et al., Growth Factors 2010 : When combined, GDF-5 did not further enhance BMP-2 induced ALP activities ... Rather, GDF-5 reduced BMP-2 induced ALP activities in both dental papilla- and follicle derived cells
Chen et al., J Bone Miner Res 2010 (Hypertrophy) : We have found that endogenous IGF-2 expression is low in MSCs. Expression of IGF-2 can potentiate BMP-9 induced early osteogenic marker alkaline phosphatase (ALP) activity and the expression of later markers ... Expression of the IGF antagonists IGFBP3 and IGFBP4 leads to inhibition of the IGF-2 effect on BMP-9 induced ALP activity and matrix mineralization
Wu et al., Acta Biochim Biophys Sin (Shanghai) 2010 : We found that three DN type II TGF-ß receptors, DN-BMPRII, DN-ActRII, and DN-ActRIIB, diminished BMP-9 induced alkaline phosphatase (ALP) activity, led to a decrease in BMP-9 induced Smad binding element ( SBE ) -controled reporter activity, reduced BMP-9 induced expressions of Smad6 and Smad7, and decreased BMP-9 induced mineralization in vitro and ectopic bone formation in vivo, finally resulted in decreased bone masses and immature osteogenesis ... Using RNA interference ( RNAi ), we found that luciferase reporter activity and ALP activity induced by BMP-9 were accordingly inhibited along with the knockdown of BMPRII and ActRII