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NOTCH1 — SLC22A3

Text-mined interactions from Literome

Timmerman et al., Genes Dev 2004 (Cell Transformation, Neoplastic) : Here we demonstrate that Notch activity promotes EMT during both cardiac development and oncogenic transformation via transcriptional induction of the Snail repressor, a potent and evolutionarily conserved mediator of EMT in many tissues and tumor types
Zavadil et al., EMBO J 2004 : Our findings identify a new mechanism for functional integration of Jagged1/Notch signalling and coordinated activation of the Hey1 transcriptional repressor controlled by TGF-beta/Smad3, and demonstrate functional roles for Smad3, Hey1, and Jagged1/Notch in mediating TGF-beta induced EMT
Moustakas et al., Cancer Sci 2007 (Cell Transformation, Neoplastic...) : Transforming growth factor-beta, Wnt, Notch and growth factors acting through tyrosine kinase receptors induce EMT and often act in a sequential manner
Yang et al., Biochem Biophys Res Commun 2008 : Here we investigate the effects of VEGF-A and Notch1 on EMT in clonal endothelial cell ( EC ) populations isolated from adult aortic valve leaflets ... A positive role for Notch1 was revealed in three experiments : ( 1 ) TGF-beta induced Notch1 mRNA in valve ECs, ( 2 ) a gamma-secretase inhibitor of Notch1 signaling blocked EMT, and ( 3 ) overexpression of a ligand independent form of Notch1 induced EMT
Chen et al., Br J Cancer 2010 (Anoxia...) : Epithelial-to-mesenchymal transition is mediated, in part, by two transcription repressors, Snail and Slug, that are known to be targets of the Notch signaling pathway, and JAGGED1 induced Notch activation increases EMT
Luna-Zurita et al., J Clin Invest 2010 : Notch1 activation in myocardium extends Hey1 expression to nonchamber myocardium, represses Bmp2, and impairs EMT
MacGrogan et al., Birth Defects Res A Clin Mol Teratol 2011 (Heart Defects, Congenital) : During cardiac valve formation, endocardial Notch signaling activates the epithelial-mesenchyme transition (EMT) that will give rise to the cardiac valve primordia
Wang et al., PloS one 2013 : To further address how these pathways coordinate in the process, we specifically disrupted Notch1 or Jagged1 in the endocardium of mouse embryonic hearts and showed that Jagged1-Notch1 signaling in the endocardium is essential for EMT and early valvular cushion formation