Gene interactions and pathways from curated databases and text-mining

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ICOS — RPL17

Text-mined interactions from Literome

Bennett et al., J Immunol 2003 : Under optimal conditions of stimulation, ICOS but not CD28 costimulation can be prevented by PD-1 engagement
Cubas et al., Nat Med 2013 (HIV Infections...) : In fact, we show that engagement of PD-1 on TFH cells leads to a reduction in cell proliferation, activation, inducible T-cell co-stimulator (ICOS) expression and interleukin-21 (IL-21) cytokine secretion