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CYBB — RAC2
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Takeya et al., Methods Enzymol 2006
:
Rac , albeit probably dispensable to the Nox3 activity,
plays an essential role in activation of
gp91phox
Miyano et al., Biochem J 2009
:
Rac1 and
Rac2 , which belong to the Rho subfamily of Ras related GTPases,
play an essential role in activation of
gp91phox/Nox2 ( cytochrome b-245, beta polypeptide ; also known as Cybb ), the catalytic core of the superoxide producing NADPH oxidase in phagocytes