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NOS2 — SPHK1
Text-mined interactions from Literome
Vann et al., J Biol Chem 2002
(Glioma) :
In contrast, enforced expression of
sphingosine kinase had no effect on
iNOS expression or NO formation
Kacimi et al., J Mol Cell Cardiol 2007
(Anoxia) :
To determine whether
SphK regulates cell proliferation and the proinflammatory protein
inducible nitric oxide synthase (iNOS) , we exposed cultured cardiac fibroblasts to the cytokine interleukin-1beta (IL-1beta) and/or hypoxia
Nayak et al., Neuroscience 2010
(Encephalitis...) :
Suppression of
SphK1 by its inhibitor, N, N Dimethylsphingosine ( DMS ), or siRNA
resulted in decreased mRNA expression of TNF-alpha, IL-1beta, and
iNOS and release of TNF-alpha and nitric oxide ( NO ) in LPS activated microglia