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KLF2 — NOS2
Text-mined interactions from Literome
SenBanerjee et al., J Exp Med 2004
(Inflammation) :
Overexpression of
KLF2 in umbilical vein endothelial cells robustly
induced endothelial
nitric oxide synthase expression and total enzymatic activity
Huddleson et al., J Biol Chem 2005
:
Finally, we have found that
KLF2 increases endothelial
nitric-oxide synthase expression in murine endothelial cultures, an effect that is also blocked by PI3K inhibition
Ali et al., J Biol Chem 2009
:
Mechanistically, synergy required Akt phosphorylation, activation of
Kruppel-like factor 2 , NF-E2 related factor-2 (Nrf2),
increased nitric-oxide synthase activity, and enhanced HO-1 mRNA stability
Boon et al., Eur Heart J 2011
(Coronary Artery Disease...) :
Lentiviral overexpression of
KLF2 increased human PAC numbers and endothelial
nitric oxide synthase expression by 60 % during in vitro culture