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CHI3L1 — MAPK14

Text-mined interactions from Literome

Michelsen et al., Atherosclerosis 2010 (Carotid Artery Diseases...) : Our main findings were : ( 1 ) serum YKL-40 levels were significantly elevated in patients with carotid atherosclerosis, with particularly high levels in those with symptomatic disease ; ( 2 ) patients with recent ischemic symptoms ( within 2 months ) had higher YKL-40 mRNA levels in carotid plaque than other patients ; ( 3 ) in vitro, the beta-adrenergic receptor agonist isoproterenol, toll-like receptor (TLR) 2 and TLR4 agonists, and in particular releasate from activated platelets significantly increased the expression of YKL-40 in THP-1 monocytes and ( 4 ) in vitro, YKL-40 increased matrix metalloproteinase-9 expression and activity in THP-1 monocytes, involving activation of p38 mitogen activated protein kinase
Faibish et al., Mol Cancer Ther 2011 (Disease Progression...) : mAY also abolished YKL-40 induced activation of the membrane receptor VEGF receptor 2 ( Flk-1/KDR ) and intracellular signaling mitogen activated protein ( MAP ) kinase extracellular signal regulated kinase ( Erk ) 1 and Erk 2
Shao et al., Frontiers in physiology 2013 : In addition, YKL-40 induces FAK-MAPK signaling and up-regulates VEGF receptor 2 in endothelial cells ; but a neutralizing antibody ( mAY ) against YKL-40 inhibits its angiogenic activity