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Khwaja et al., Kidney Int 2005
(MAP Kinase Signaling System) :
FTS ( 10-20 micromol/L ) inhibited both Ras and phospho-MAPK activation by serum and PDGF
Gana-Weisz et al., Biochem Biophys Res Commun 1997
:
FTS also inhibits MAPK activity and DNA synthesis stimulated by serum, EGF or thrombin in serum starved untransformed Rat-1 cells, demonstrating the generality of its effects on Ras dependent signaling ... The effects of FTS on MAPK activity developed relatively rapidly ( within 2-6 h ) consistent with its rapid effect on Ras membrane anchorage