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LYN — PTPRC

Pathways - manually collected, often from reviews:

• KEGG Fc gamma R-mediated phagocytosis: PTPRC → HCK/LYN (protein-protein, activation)
• NCI Pathway Database BCR signaling pathway: LYN (LYN) → CD45 (PTPRC) (modification, collaborate) Katagiri et al., J Biol Chem 1995

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: LYN — PTPRC (physical association, affinity chromatography technology) Brown et al., J Biol Chem 1994*
• IRef Biogrid Interaction: LYN — PTPRC (direct interaction, pull down) Brown et al., J Biol Chem 1994*
• IRef Hprd Interaction: LYN — PTPRC (in vivo) Katagiri et al., J Immunol 1999*, Harashima et al., Blood 2002*
• IRef Hprd Interaction: LYN — PTPRC (in vitro) Katagiri et al., J Immunol 1999*, Harashima et al., Blood 2002*

Text-mined interactions from Literome

Shrivastava et al., Blood 2004 : We previously demonstrated that CD45 negatively regulates Lyn in the WEHI-231 B-cell line
Zhou et al., Int J Hematol 2004 (Multiple Myeloma) : Additionally, IL-6 induced Lyn kinase activity in CD45+ U266 cells was increased by the cross linking of CD45 , and this increase was due to the dephosphorylation of Tyr507 at Lyn
Flores-Borja et al., Arthritis Rheum 2007 (Lupus Erythematosus, Systemic) : Kinetic studies revealed that translocation of Lyn, CD45 , Csk, and c-Cbl led to increased recruitment and retention of Lyn and CD45 in the BCR-antigen synapse in SLE B cells