◀ Back to IRF6

IRF6 — SETD2

Text-mined interactions from Literome

Blouin et al., Blood 2004 : In functional studies, the LPS induced HIF-1 complex could specifically bind to the HIF-1 DNA binding motif
Frede et al., Biochem J 2006 (Anoxia) : LPS and hypoxia synergistically activated HIF-1
Oh et al., Neurosci Lett 2008 (Anoxia) : Thus, we examined effect of lipopolysaccharide (LPS) on HIF-1 activation and its signaling mechanism in BV2 microglial cells ... LPS induced HIF-1alpha mRNA and protein expression as well as HIF-1 transcriptional activation
Nishi et al., Antioxid Redox Signal 2008 : In this study, we demonstrated that lipopolysaccharide (LPS) induces HIF-1 activation by enhancing both HIF-1alpha protein expression through a translation dependent pathway and HIF-1alpha transcriptional activity in THP-1 human myeloid cells that have undergone macrophage differentiation but not in undifferentiated monocytic THP-1 cells ... LPS induced HIF-1 activation was blocked by treatment with antioxidant ( N-acetylcysteine or thioredoxin-1 ), NADPH oxidase inhibitor ( diphenyleneiodonium ), indicating that reactive oxygen species generated in response to LPS are essential in this process ... LPS mediated activation of HIF-1 was independent of NF-kappaB activity ... LPS induced ROS generation and HIF-1 activation required the expression of Toll-like receptor 4 or myeloid differentiation factor (MyD) 88, thus providing a molecular basis for the selective activation of HIF-1 in differentiated THP-1 cells
Mi et al., Cell cycle (Georgetown, Tex.) 2008 : Interestingly, LPS did not significantly affect HIF-1alpha protein levels or HIF-1 DNA binding activity relative to hypoxic induction ... Addition of ROS-scavengers completely abrogated the synergistic induction of HIF-1 transcriptional activity by LPS and hypoxia, but neither inhibited HIF-1 transcriptional activity induced by hypoxia alone nor affected HIF-1alpha protein levels or HIF-1 DNA binding induced by hypoxia alone or hypoxia plus LPS
Tacchini et al., J Biol Chem 2008 (Inflammation) : Activation of an anti-inflammatory pathway by pre-exposure to the adenosine A(2A) receptor agonist CGS21680 prevented the inducing effect of LPS/IFNgamma on HIF-1 and TfR1 expression by inhibiting NF-kappaB activity, whereas treatment with CGS21680 alone increased HIF-1 mediated TfR1 expression by means of an NF-kappaB independent signaling pathway
Ramanathan et al., J Leukoc Biol 2009 : LPS/NECA induced expression of HIF-1alphaI.1 was down-regulated by Bay 11-7085 ( NF-kappaB inhibitor ) and ZM241385 ( A ( 2A ) R antagonist )
Labuzek et al., Naunyn Schmiedebergs Arch Pharmacol 2010 (Inflammation) : The observed alterations in the release or production of inflammatory mediators may be explained by the changes in NF-kappaB, HIF-1 alpha, and arginase I expression and 3- ( 4,5-dimethylthazol-2-yl ) -2,5-diphenyltetrazolinum bromide values in response to LPS , whereas the basis for the compound C effect on non stimulated microglia remains to be investigated
Hsieh et al., Phytomedicine 2011 (Bone Resorption...) : In addition, icariin had a dominant repression effect on LPS induced hypoxia inducible factor-1a (HIF-1a) expression of osteoclasts
Xu et al., Am J Respir Cell Mol Biol 2011 (Acute Lung Injury...) : TIIA did not affect the LPS induced HIF-1a mRNA level but inhibited HIF-1a protein translation by the inhibition of the PI3K/AKT and MAPK pathways and related protein translational regulators, such as p70S6K1, S6 ribosomal protein, 4E-BP1, and eIF4E, and promoted HIF-1a protein degradation via the proteasomal pathway in LPS stimulated macrophages
Chang et al., American journal of physiology. Renal physiology 2013 (Anoxia) : In the present study, we showed that both lipopolysaccharide (LPS) and hypoxia induced B7-1 and hypoxia-inducible factor (HIF)-1a expression in podocytes
Ehrentraut et al., J Immunol 2013 : HMECs with an intact neddylation pathway showed a time dependent induction of Cul-1 neddylation, nuclear translocation of NF-?B, stabilization of HIF-1a , and increased NF-?B/HIF-a promoter activity in response to LPS
Kim et al., Scientific reports 2013 (Pneumonia) : Moreover, LPS induced increases of NF-?B and HIF-1a activity were lowered by inhibition of ER stress