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CYP3A — IRF6
Text-mined interactions from Literome
Pan et al., Drug Metab Dispos 2003
:
These data clearly demonstrate that
LPS mediated modulation of
CYP3A11 , 2B10, 2C29, 1A2, and 4A10 in mouse liver is Stat1 independent
Xu et al., Free Radic Biol Med 2004
:
The in vivo
effects of
lipopolysaccharide (LPS) on expression of PXR and its target gene
cytochrome P450 3A (CYP3A) in mouse liver were investigated in this study ...
LPS also
represses the upregulation of
CYP3A11 mRNA levels and erythromycin N-demethylase ( ERND ) catalytic activity in mice pretreated with PXR ligands dexamethasone, rifampicin, mifepristone, and phenobarbital ... These antioxidants also prevented the repressive
effects of
LPS on dexamethasone-, rifampicin-, mifepristone-, and phenobarbital-inducible
CYP3A11 mRNA expression and ERND catalytic activity in mouse liver ... These results indicate that Kupffer cells contribute to
LPS induced downregulation of PXR and
CYP3A in mouse liver ... Reactive oxygen species, produced possibly by NADPH oxidase and perhaps by xanthine oxidase, are involved in
LPS induced downregulation of nuclear receptor PXR and its target gene
CYP3A in mouse liver
Xu et al., J Pineal Res 2005
:
Our earlier study indicated that reactive oxygen species contribute to
lipopolysaccharide (LPS) induced down-regulation of PXR and its target gene
CYP3A in mouse liver ... In this study, we investigated the effects of melatonin on
LPS induced down-regulation of PXR and
CYP3A in mouse liver ... Repeated doses of melatonin ( 10 mg/kg ) treatments also significantly attenuated
LPS induced down-regulation of dexamethasone-inducible
CYP3A11 mRNA level and ERND activity in mouse liver ... These findings suggest that melatonin may exert its protective effects on
LPS induced down-regulation of PXR and
CYP3A via counteracting LPS induced oxidative stress in mouse liver
Chen et al., Toxicology 2005
:
Lipopolysaccharide (LPS) induced downregulation of PXR,
CYP3A and MDR1 in liver has been demonstrated in a series of studies ... However, it is not clear whether
LPS represses the expression of PXR,
CYP3A and MDR1 in placenta
Goralski et al., Am J Physiol Gastrointest Liver Physiol 2005
(Central Nervous System Diseases...) :
The loss of
Cyp3a11 in
response to centrally or peripherally administered
LPS could not be evoked in Toll-like receptor-4 (TLR4)-mutant ( C3H/HeJ ) mice, indicating that TLR4 signaling pathways are directly involved in the enzyme loss
Kato et al., Innate Immun 2008
(Disease Models, Animal...) :
In this study, we investigated the
effects of
lipopolysaccharide (LPS) on hepatic total cytochrome P450 ( CYP ),
CYP3A2 , and CYP2C11 contents in a transient, LPS induced, endotoxemia model of rats