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IL8 — NOX1

Text-mined interactions from Literome

Dhaunsi et al., J Biomed Sci 2003 (Coronary Disease...) : Diphenylene iodonium, an inhibitor of NADPH oxidase , significantly inhibited CMV induced IL-8 production and promotion of serum induced DNA synthesis
Yamagishi et al., J Cardiovasc Pharmacol 2004 : These results demonstrated that azelnidipine inhibited TNF-alpha induced IL-8 expression in HUVEC by blocking NADPH oxidase mediated ROS generation and subsequent AP-1 activation
Tojo et al., J Hypertens 2005 (Hypertension, Renal) : Nicotinamide adenine dinucleotide phosphate ( NAD ( P ) H ) oxidase is regulated by angiotensin II, interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha via p38 mitogen activated protein kinase ( MAPK )
Nakamura et al., Med Hypotheses 2005 (Arteriosclerosis...) : In the process of the search for such a unique anti-hypertensive drug, we have recently found that azelnidipine, a newly developed and commercially used long acting dihydropyridine based calcium antagonist ( DHP ), inhibited TNF-alpha induced activator protein-1 activation and interleukin-8 expression in human umbilical vein endothelial cells by suppressing NADPH oxidase mediated reactive oxygen species generation
Guichard et al., J Biol Chem 2005 : Interleukin-8 (IL-8) does not activate NADPH oxidase , but potentiates the oxidative burst induced by stimuli such as formyl-methionyl-leucyl-phenylalanine ( fMLP ) via a priming mechanism
Al Ghouleh et al., Shock 2008 : Inhibition of NADPH oxidase with the short interfering RNA reduced the induction by LPS of intracellular adhesion molecule 1 mRNA, protein, and IL-8 release ( by enzyme linked immunosorbent assay )
Choi et al., Atherosclerosis 2010 : This study suggests that GSA induces expression of IL-8 in VSMCs and that TLR-4, mitogen activated protein kinases, NF-kappaB, and NADPH oxidase are involved in that process
Kim et al., J Immunol 2010 : We also characterized the BLT2 downstream signaling pathway and determined that BLT2 mediated IL-8 synthesis involves the upregulation of Nox1 , a member of the NADPH oxidase family, Nox1 dependent reactive oxygen species generation and the subsequent activation of the redox-sensitive transcription factor NF-kappaB
Miyoshi et al., Immunology 2010 (Sepsis) : We further discovered that NADPH oxidase (Nox) 1 expression in LPS stimulated HUVECs was markedly repressed by IL-8 knockdown, and Nox1 knockdown reduced tissue factor expression, suggesting that the LPS/IL-8 signalling in endothelial cells was predominantly mediated by Nox1
Chattoraj et al., Thorax 2011 (Cystic Fibrosis...) : Inhibition of NADPH oxidase reduced bacterial transmigration across mucociliary differentiated CF cells and the interleukin-8 response in MPA- and RV-infected cells
Tang et al., Free Radic Biol Med 2011 (Pneumonia) : Here, we show that cigarette smoke extract sequentially activated NADPH oxidase ; increased intracellular reactive oxygen species ( ROS ) level ; activated AMPK, NF-?B, and STAT3 ; and induced interleukin 8 (IL-8) in human LECs ... Inhibition of NADPH oxidase activation by apocynin or siRNA targeting p47(phox) ( a subunit of NADPH oxidase ) attenuated the increased intracellular ROS level, AMPK activation, and IL-8 induction
Perng et al., Crit Care Med 2013 (Inflammation...) : Inhibition of NADPH oxidase activation with apocynin or siRNA targeting p47 ( phox ) ( a subunit of NADPH oxidase ) attenuated the increased intracellular reactive oxygen species level, AMP activated protein kinase activation, and interleukin-8 induction
Silliman et al., Transfusion 1996 : Because 46 percent of the priming activity from whole-blood platelets was chloroform insoluble and because it has been reported that interleukin 8 is generated during routine storage of whole-blood platelets, the effects of interleukin 8 on the NADPH oxidase were examined