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CD44 — FAS

Text-mined interactions from Literome

Yasuda et al., Histol Histopathol 2002 (Colonic Neoplasms...) : The interaction of CD44 with fragmented hyaluronan on rheumatoid synovial cells induces expression of VCAM-1 and Fas on the cells, which leads to Fas mediated apoptosis of synovial cells by the interaction of T cells bearing FasL ... On the other hand, engagement of CD44 on tumor cells derived from lung cancer reduces Fas expression and Fas mediated apoptosis, resulting in less susceptibility of the cells to CTL mediated cytotoxicity through Fas-FasL pathway
De Saint Jean et al., Exp Eye Res 2004 : In the primary cultured cells, TNFalpha induced an important upregulation of ICAM-1, Fas and CD40 whereas CD44 and CD63 were significantly decreased
Li et al., Cancer Immunol Immunother 2006 (Neoplasms) : The TM-TNFalpha expressing tumors up-regulated Fas ( CD95 ) expression and inhibited the expression of tumor metastasis associated molecule CD44v3
Nakano et al., Apoptosis 2007 (Calcium Signaling) : Furthermore, AICD induced by CD3 restimulation was inhibited by hyaluronidase as well as by soluble Fas , indicating an interaction between membrane bound hyaluronan and the cell surface CD44 was involved in the up-regulation of FasL expression on T cells and subsequent AICD