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E2F1 — TCF4
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
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Gene Ontology Complexes transcription factor complex:
transcription factor complex complex (ATF7IP-GSC-GCM1-MAFB-NKX2-1-NKX2-5-RARG-KLF4-FOXF1-FOXF2-FOXE3-LDB1-ZFHX3-GATA6-SNAI3-FOXH1-KAT5-AHR-EYA3-NFATC2-CRX-MED27-HES6-SKI-XRCC6-ARNTL-SUB1-JUN-SOX17-SCX-DMBX1-TCF4-TCF7-PDLIM1-TFEB-LBX1-TRRAP-NAA16-EPAS1-MGA-PTF1A-HOXD12-MEF2B-TFDP3-TFDP1-HDAC2-YY1-SMAD9-CLOCK-ONECUT3-SMAD5-SMAD6-SMAD7-SMAD1-SMAD2-PRKDC-RCOR2-NHLH2-REL-TBX5-ARNTL2-BSX-HOXA10-HOXB13-MED23-PUS1-TAL1-RBL1-RBL2-MINA-HMGA1-BARX2-LEF1-EP300-PMF1-ARID5A-WWTR1-LMO2-LMO4-TP73-ABT1-CDK2-DKFZp686M216-CREG1-CTNNB1-SOX9-HAND2-SOX2-TEAD2-MYOG-TEAD4-CEBPA-GFI1B-MYOD1-ALX1-NPAS4-TFAP2D-FIGLA-ALX4-ETS1-PROP1-ASCL3-HCLS1-MSX1-MSX2-SRA1-AJUBA-MTA2-SIN3A-POU3F2-POU3F1-BEX1-MLXIPL-NR2E3-PBX2-ANKRD1-E2F6-E2F5-E2F4-E2F3-E2F2-E2F1-E2F8-CREBBP-ATF5-ATF4-POU2F3)
Kaspar et al., J Biol Chem 1999, Wang et al., J Biol Chem 1999, Nagpal et al., J Biol Chem 1999, Blixt et al., Genes Dev 2000, Carlberg et al., Mol Cell Biol Res Commun 2000, Bae et al., Development 2000, Cairo et al., Hum Mol Genet 2001, Tutter et al., Genes Dev 2001, Willis et al., J Biol Chem 2002, Bayne et al., Mol Hum Reprod 2004, Schubert et al., J Biol Chem 2004, Han et al., J Mol Biol 2005, Rodriguez et al., EMBO J 2005, Han et al., Nucleic Acids Res 2005, Zhang et al., Mol Cell Biol 2007, Wong et al., Cell 2009, Stevens et al., Immunology 2009, Stefanovic et al., J Cell Biol 2009, Skokowa et al., Nat Med 2012, Ge et al., Cell 1994, Durocher et al., EMBO J 1997, Hogenesch et al., Proc Natl Acad Sci U S A 1998, Hellqvist et al., J Biol Chem 1998, Ryu et al., Nature 1999
Text-mined interactions from Literome
Leone et al., Mol Cell 2001
:
Previous work has shown that the Myc
transcription factor induces transcription of the E2F1,
E2F2 , and E2F3 genes ... Previous work has shown that the Myc
transcription factor induces transcription of the
E2F1 , E2F2, and E2F3 genes
Kim et al., Hypertension 2005
(Carotid Artery Injuries) :
In the present study, we examine whether the antiproliferative effect of cilostazol on VSMCs is
mediated by inhibition of an important cell cycle
transcription factor ,
E2F
Hanada et al., Mol Carcinog 2006
:
Also found in breast tumors with high levels is B-Myb, a
transcription factor whose expression is
activated by
E2F1/3 at the late G1 phase and the level is sustained through the S phase
Wang et al., J Biol Chem 2007
:
Here we report that KAP1 binds the E2F1
transcription factor in a retinoblastoma protein ( pRb ) -independent fashion and
inhibits E2F1 activity
Abramova et al., Biochem Biophys Res Commun 2010
:
Here we show that e2f1 expression is regulated through the Wnt/Tcf-pathway :
e2f1 promoter activity is
inhibited by sodium butyrate ( NaB ) and by overexpression of
beta-catenin/Tcf
Xie et al., J Cell Mol Med 2009
:
E2F1 represses
beta-catenin/TCF activity by direct up-regulation of Siah1 ... Moreover,
repression of
beta-catenin/TCF activity by
E2F1 can be attenuated by shRNA based repression of endogenous Siah1, implying that Siah1 is a bona fide E2F1 target gene, which at least partly, mediates the suppression of beta-catenin/TCF signalling pathway
Coleman et al., Journal of oncology 2010
:
T-oligos activated the transcription factor
E2F1 and
inhibited the activity of the angiogenic
transcription factor , HIF-1alpha
Knoll et al., Adv Exp Med Biol 2013
(Disease Progression...) :
MiRs are activated by
E2F1 and either the
transcription factor itself or cellular genes necessary for the growth regulating function of E2F1 are
inhibited by different miRNAs
Defeo-Jones et al., J Virol 1993
(Cell Transformation, Viral...) :
We now show by mutational analysis that the CRPV E7 protein 's biochemical and biological properties, including binding to the retinoblastoma suppressor protein ( pRB ),
transcription factor E2F transactivation of the adenovirus E2 promoter, disruption of pRB-E2F complexes, and cellular transformation as measured by growth in soft agar, mimic those of the HPV E7 protein