◀ Back to CSF2

CSF2 — SYK

Pathways - manually collected, often from reviews:

• NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB (dimer)/LYN/SYK complex (CSF2RB-LYN-SYK-CSF2-CSF2RA) → GMCSF/GMR alpha/CSF2RB (dimer)/LYN complex (CSF2RB-LYN-CSF2-CSF2RA) (modification, collaborate)
  Yousefi et al., J Exp Med 1996
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB (dimer)/LYN/SYK complex (CSF2RB-LYN-SYK-CSF2-CSF2RA) → SYK (SYK) (modification, collaborate) Yousefi et al., J Exp Med 1996
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB (dimer)/LYN complex (CSF2RB-LYN-CSF2-CSF2RA) → SYK (SYK) (modification, collaborate) Yousefi et al., J Exp Med 1996
  Evidence: mutant phenotype, physical interaction

Text-mined interactions from Literome

Kedzierska et al., J Leukoc Biol 2001 : FcgammaR mediated phagocytosis by human macrophages involves Hck, Syk , and Pyk2 and is augmented by GM-CSF
Jinquan et al., J Immunol 2001 : Thus, GM-CSF binds to its receptor CD116, and consequently activates Syk phosphorylation, which leads to induce CXCR3 expression ... Interestingly, gamma IP-10 and Mig can induce chemotaxis and adhesion in GM-CSF stimulated Syk- or Cbl blocked CD34 ( + ) hemopoietic progenitors
Zou et al., J Biol Chem 2009 : Expression of nonphosphorylatable Syk ( Y317F ) in primary Syk ( -/- ) OCs enhances M-CSF- and alphavbeta3 induced phosphorylation of the cytoskeleton organizing molecules, SLP76, Vav3, and PLCgamma2, to levels greater than wild type, thereby accelerating the resorptive capacity of the cell
Tweardy et al., Blood 1995 : Binding of granulocyte colony stimulating factor ( G-CSF ) to normal myeloid cells activates the protein tyrosine kinases Lyn and Syk and results in the immediate early upregulation of G-CSF receptor (R) mRNA